Cardiotoxicity associated with 5-flurouracil – A case series
Journal Title: National Journal of Physiology, Pharmacy and Pharmacology - Year 2018, Vol 8, Issue 1
Abstract
5-flurouracil (5-FU) is a frequently administered chemotherapeutic drug in various malignant neoplasms. We report four cases of cancer patients who were exposed to 5-FU and which resulted in cardio toxicity. Patients developed supraventricular tachycardia, sinus bradycardia, cardiomyopathy, and acute coronary vasospasms. In all cases, the events were reversible. Except in case of cardiomyopathy the chemotherapy was continued without any further issues. All the observed adverse drug reactions (ADR) were carefully studied and the causality was assessed using Naranjo ADR probability scale.
Authors and Affiliations
Jisha S Das, Naveen Kumar Panicker
Keywords
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- EP ID EP450366
- DOI 10.5455/njppp.2018.8.0726902082017
- Views 76
- Downloads 0
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