Cardiovascular complications of selected antibodies used in oncological immunotherapy
Journal Title: OncoReview - Year 2017, Vol 7, Issue 2
Abstract
Immunotherapy supports other therapeutic methods and is an important element in the fight against cancer. Its main tasks include stimulation and guidance of the immune system to fight cancer, inhibition of the mechanisms that block the immune system, and direct destruction of neoplastic cells. Different from chemotherapy or hormonal therapy, its mechanism of action is associated with a different profile of adverse events. HER2 receptor inhibitors may cause symptoms of heart failure, which usually recede, once the treatment has been discontinued. Bevacizumab, an anti-VEGF antibody, induces numerous cardiovascular complications, including arterial hypertension, arterial embolism, haemorrhage and haemoptysis as well as venous thromboembolism.
Authors and Affiliations
Joanna Kufel-Grabowska
Keywords
Related Articles
- EP ID EP189007
- DOI 10.24292/01.OR.300617.4
- Views 201
- Downloads 0
Diagnostyka i leczenie akromegalii
Akromegalia jest chorobą przewlekłą, wywołaną nadmiernym wydzielaniem hormonu wzrostu i wtórnie podwyższonym stężeniem insulinopodobnego czynnika wzrostu 1 (IGF-1). Nieleczona lub nieprawidłowo leczona choroba skutkuje r...
Znaczenie inhibitorów aromatazy w leczeniu chorych na raka piersi
Leczenie hormonalne raka piersi ma na celu ograniczenie oddziaływania endogennych estrogenów na komórki nowotworu. Odkrycie receptorów hormonalnych i poznanie ich znaczenia umożliwiło zastosowanie hormonoterapii w celowa...
Pericardiocentesis and pericardial therapy aspects in cancer patients - a case report
The malignancy related pericardial effusion has variable dynamics, and the clinical presentation and severity of symptoms are directly related to the degree of hemodynamic conditions and the rate of fluid accumulation in...
Everolimus – effectively reverses acquired resistance on endocrine therapy of patients with advanced breast cancer. A case report
Breast cancer is the most common malignancy among women in Poland. Endocrine therapy is the first line of treatment in hormone-receptor-positive advanced breast cancer. Progression during endocrine therapy is unavoidable...
Percutaneous vena cava superior angioplasty and stenting as an effective method of treatment in vena cava superior syndrome in the course of lung cancer
Vena cava superior syndrome (VCSS) is a sudden life-threatening condition encountered in patients with neoplasms. The prognosis depends on histopathological diagnosis, severity of clinical symptoms and administered treat...