CARDIOVASCULAR MANIFESTATIONS IN PATIENTS OF HYPOTHYROIDISM- RESULTS OF A SINGLE CENTRE STUDY
Journal Title: Journal of Evolution of Medical and Dental Sciences - Year 2017, Vol 6, Issue 45
Abstract
BACKGROUND Objective- To examine cardiovascular manifestations in patients with hypothyroidism. MATERIALS AND METHODS In this observational study, adult hypothyroid patients were screened for cardiovascular disease. Symptoms of hypothyroidism, cardiovascular system related symptoms, T3, T4 and Thyroid Stimulating Hormone (TSH) were compared between male and female patients. Association between thyroid stimulating hormone and heart disease was also evaluated. RESULTS Hundred patients (male 32% and female 68%) with mean age of 39.2 + 9.28 years were enrolled. More number of females showed weight gain over a period of two years as compared to males (p= 0.0217). Dry skin was more common in females as compared to males (p= 0.0336). More females reported breathlessness and chest pain as compared to males (breathlessness p= 0.0187; chest pain p= 0.0008). Pulse rate of female patients was significantly lower than male patients (p= 0.0081). More number of females had raised jugular venous pressure as compared to males (41% vs 19%, p= 0.0475). Diastolic blood pressure was higher in females than in males (p= 0.023). There was no difference in the mean T3 (52.43 ± 14.35 pg/mL vs 46.53 ± 14.19 pg/mL; p= 0.1776), T4 level (4.48 ± 0.97 vs 4.06 ± 0.97; p= 0.1630) or TSH level (31.19 ± 11.9 vs 42.21 ± 26.98; p= 0.1260) between males and females. Number of females with cardiomegaly was higher compared to males [26 (38%) vs 2 (6%); p < 0.0001]. Significant association was observed between higher TSH and presence of breathlessness, chest discomfort and palpitations (p < 0.05). Significantly, more patients with higher TSH showed significantly more heart rate, raised jugular venous pressure and diastolic blood pressure (p < 0.05). Higher TSH was associated with pericardial effusion in more proportion of patients (p= 0.007). CONCLUSION Cardiac dysfunction is common in patients with hypothyroidism. Screening and treatment of cardiovascular disease in hypothyroidism may help to reduce morbidity and mortality in hypothyroidism.
Authors and Affiliations
Rohit Vasant Deshpande, Swati Harish Sharma, Swapnil Sahebrao Walke, Mayur Ramakrishnarao Hedau, Bharat Sing Rathod, Amol Raghunath Bhore, Hitesh Lotan Mahale
Keywords
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- EP ID EP216823
- DOI 10.14260/Jemds/2017/758
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