Carotid Artery Disease in Patients with Chronic Kidney Disease
Journal Title: Journal of Medical Science And clinical Research - Year 2015, Vol 3, Issue 4
Abstract
Objective: 1. To study the prevalence of carotid artery disease in patients with chronic kidney disease using carotid artery intima media thickness as a surrogate marker, measured by B mode ultrasonography. 2. To study the co relation of carotid intima media thickness with glomerular filtration rate and other cardiovascular risk factors Background: The present study is aimed at studying the prevalence of atherosclerosis in patients with CKD using carotid intima media thickness (CIMT) as a surrogate marker of atherosclerosis and co relating the various CVD risk factors and declining renal function in the causation of atherosclerosis. Materials And Methods: Seventy patients with CKD, defined by NKF/KDOQI guidelines, attending nephrology OPD were studied for demographic data and CIMT values and comparing with thirty age and sex matched controls. CIMT was derived via B-mode ultrasonography and CKD was evaluated by the estimated glomerular filtration rate (eGFR) using the Modification of Diet in Renal Disease Study equation. Results: Mean CIMT in CKD patients was 0.86± 0.21 mm and that in healthy age and sex matched controls was 0.63±0.17mm which was statistically significant (P = 0.001). Univariate correlation analysis has revealed a strong correlation between CIMT and age (r = 0.605 P < 0.000), BMI (r = 0.377, P = 0.002), Serum Cholesterol (r = 0.236. P= 0.018) and Serum Triglyceride levels (r = 0.387, P = < 0.001) and eGFR (r= -0.02, p <0.001). Conclusions: Patients with CKD are associated with greater risk of atherosclerosis as compared to the general population. CIMT, used as a surrogate marker of atherosclerosis is significantly higher in CKD patients when compared to healthy controls. The exact pathogenesis of accelerated atherosclerosis in CKD patients is unclear but probably involves interplay of traditional and uremia related risk factors.
Authors and Affiliations
Satish Reddy N
Keywords
Related Articles
- EP ID EP211316
- DOI -
- Views 80
- Downloads 0
Effect of Aerobic Exercise on Common Peroneal Nerve Conduction in Post Burn Children
Purpose: to determine the effect of aerobic exercise on common peroneal nerve conduction in post burn children. Methods of Evaluation: (Measurement of motor common peroneal nerve conduction velocity). Subjects: Forty chi...
Prevalence and Risk Factors of Hypertension among Geriatric Population in Rural Area of Katihar, Bihar
Abstract Background: Ageing is a biological process and not a disease or curse, and during the biological process significant changes occur in human body. However ageing is inevitable, irreversible and progressive. Devel...
Centchroman Regress Mastalgia and Fibroadenoma: An Institutional Study
Objectives: Centchroman (also known as Ormeloxifene) is one of the selective estrogen receptor modulators, or SERMs, a class of medication which acts selectively on the estrogen receptor. Because of its selective antiest...
Role of Barever Natural Hair Inhibitor in Reducing Unwanted Body Hair Growth; As an Adjuvant Therapy with Waxing and with Normal Hair Removal Cream
Unwanted facial and body hair plays role in one’s cosmetic look, although unwanted hair is not detrimental to health but it is considered to affect the perfect look of person. Unwanted hair on the visible body parts like...
Diode Laser Surgery of Multiple Traumatic Fibromas of the Buccal Mucosa in Patient Taking Oral Anticoagulant: Conventional and Confocal Laser Scanning Microscopical Examination
To report on a case of multiple traumatic fibromas of the buccal mucosa surgically removed by diode laser (wavelength 980nm, laser set to 1,5 Watt in continuous wave, fibre of 300micron in diameter) in a patient receivin...