Carotid Artery Disease in Patients with Chronic Kidney Disease
Journal Title: Journal of Medical Science And clinical Research - Year 2015, Vol 3, Issue 4
Abstract
Objective: 1. To study the prevalence of carotid artery disease in patients with chronic kidney disease using carotid artery intima media thickness as a surrogate marker, measured by B mode ultrasonography. 2. To study the co relation of carotid intima media thickness with glomerular filtration rate and other cardiovascular risk factors Background: The present study is aimed at studying the prevalence of atherosclerosis in patients with CKD using carotid intima media thickness (CIMT) as a surrogate marker of atherosclerosis and co relating the various CVD risk factors and declining renal function in the causation of atherosclerosis. Materials And Methods: Seventy patients with CKD, defined by NKF/KDOQI guidelines, attending nephrology OPD were studied for demographic data and CIMT values and comparing with thirty age and sex matched controls. CIMT was derived via B-mode ultrasonography and CKD was evaluated by the estimated glomerular filtration rate (eGFR) using the Modification of Diet in Renal Disease Study equation. Results: Mean CIMT in CKD patients was 0.86± 0.21 mm and that in healthy age and sex matched controls was 0.63±0.17mm which was statistically significant (P = 0.001). Univariate correlation analysis has revealed a strong correlation between CIMT and age (r = 0.605 P < 0.000), BMI (r = 0.377, P = 0.002), Serum Cholesterol (r = 0.236. P= 0.018) and Serum Triglyceride levels (r = 0.387, P = < 0.001) and eGFR (r= -0.02, p <0.001). Conclusions: Patients with CKD are associated with greater risk of atherosclerosis as compared to the general population. CIMT, used as a surrogate marker of atherosclerosis is significantly higher in CKD patients when compared to healthy controls. The exact pathogenesis of accelerated atherosclerosis in CKD patients is unclear but probably involves interplay of traditional and uremia related risk factors.
Authors and Affiliations
Satish Reddy N
Keywords
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