CASE REPORT: A RARE PRESENTATION OF HEMOGLOBIN D TRAIT
Journal Title: Journal of Evolution of Medical and Dental Sciences - Year 2013, Vol 2, Issue 49
Abstract
Hemoglobin D Punjab was first discovered in the early fifties in a mixed British and American family of Indian origin from the Los Angeles area; hence it is also sometimes called as “D Los Angeles”. Hemoglobin D is the 4th common hemoglobin variance. It developed as a response to the selective pressures of malaria in these regions. The substitution in Hb D is a glutamic acid to glutamine at the 121stamino acid of the beta -globin chain (121Glu Gln). Hb D has an S-like mobility on alkaline electrophoresis but co-migrates with HbA on acid pH. Osmotic fragility may be decreased. Blood films may show target cells. [1]
Authors and Affiliations
Mythri S, Chikkalingiah , Keshava
Keywords
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