Case Report of Attenuated-Responsiveness to Coartem® in Western Kenya
Journal Title: International Journal of Medical and Pharmaceutical Case Reports - Year 2015, Vol 2, Issue 1
Abstract
We describe a case of attenuated-responsiveness to Artemether-Lumefantrine (AL) in western Kenya. A 4-year old patient with 14% parasitemia was treated with Coartem® but on day 7 still had 5% parasitemia. Parasite genetic profile had similar genetic polymorphism as that selected for when AL is administered. In vitro analysis revealed elevated IC50s for AL components compared to the reference P. falciparum clone 3D7 and samples collected at this site over the last 5 years. There is need for continued global surveillance to effectively manage emergence and spread of artemisinin drug resistance which has now been found in Southeast Asia.
Authors and Affiliations
Edwin Kamau, Hoseah M. Akala, Angela O. Achieng, Redemptah Yeda, Luicer A. Ingasia, Agnes C. Cheruiyot, Dennis W. Juma, Charles Okudo, Duke Omariba, Catherine Muriuki, Eunice A. Owiti, Patrick Omondi, Amos Otedo, Ben Andagalu, Bernhards Ogutu
Keywords
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- EP ID EP343635
- DOI 10.9734/IJMPCR/2015/11141
- Views 85
- Downloads 0
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