Caspr 2 antibody associated disease-An unusual presentation
Journal Title: Indian Journal of Neurosciences - Year 2018, Vol 4, Issue 2
Abstract
Introduction Antibodies to Voltage Gated Potassium Channels VGKC are directed against Leucinerich Glioma Inactivated1 LGI1 and Contactin Associated Protein like 2 Caspr2 Common presentations of Caspr2 antibody associated diseases include limbic encephalitis Morvanrsquos syndrome and acquired neuromyotonia New clinical phenotypes are being considered to the spectrum of Caspr2 antibody associated disease Here we report a case of Caspr2 antibody associated disease with an unusual clinical presentationCase Report 40 year old male presented with distal symmetrical sensorimotor neuropathy of 4 months duration Subsequently he had developed neurobehavioral symptoms in the form of irritability episodic memory impairment and seizures After medical evaluation he was diagnosed to have anti Caspr2 antibody associated disease Patient showed improvement with an immunosuppressive therapy but had recurrence of autoimmune encephalitis 1 month later Along with that he had also developed right vocal cord palsy for which no other cause was identified Patient improved with second line immunosuppressive therapy He had no further recurrence and is under follow upKeywords Voltage gated potassium channels Leucinerich Gliomainactivated 1 Contactin associated protein Limbic encephalitis Neuromyotonia
Authors and Affiliations
Vishal V Panicker, Shaji C V, Nikhil Gladson, Jithin Raj, Kabeer K A
Keywords
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