Catalase polymorphism May Influence the Pathogenesis of Diabetes Mellitus
Journal Title: Journal of Endocrinology and Diabetes - Year 2016, Vol 3, Issue 6
Abstract
Diabetes is a heterogeneous disease where many factors are involved in its pathogenesis. The genotype frequency of Catalase (CAT) microsatellite polymorphism in patients with Type 1-Diabetes (T1DM) was analysed. 86 T1DM patients (37M: 49F) and 81 no’86 T1DM patients (37M: 49F) and 81 normal controls (43M: 38F) were included in the investigation. The diabetic controls (DC) had an average age of 34.0 years ± 2.84 SEM (n=7, 3M: 4F), a mean duration of disease of 27.9 years ± 2.46 SEM and did not have any diabetic complications for at least 20 years. Patients with diabetic nephropathy (n=16, 7M: 9F) were on average 47.3 years ± 5.54 SEM and had been diagnosed for 30.8 years ± 2.94 SEM. There was also a group of patients that had been diagnosed for a short duration (SD) with a mean age of 21.7 years ± 2.60 SEM (n=8, 5M: 3F). A further 55 patients (21M:24F) had been diagnosed for 18.4 years ±1.30 SEM; mean age of 26.7 years ± 1.13SEM but no complications were recorded and not eligible to be included in the DC group being diagnosed for less than 20 years. Significant differences reported between patients with diabetes (n=86, 37M: 49F) and normal healthy controls (n=81,43M:38F). Patients with diabetes had a higher percentage of heterozygous copies (54%; Chi-square=5.87; p=0.01); normal controls had a higher homozygous percentage (63%; Chi-square=6.5; p=0.01). Conclusion This is the first reported polymorphism of CAT that may be associated with the cellular damage causing the onset of diabetes
Authors and Affiliations
Annwyne Houldsworth, Andrea Hodgkinson, Andy Demaine, Ann Millward
Keywords
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- EP ID EP333709
- DOI 10.15226/2374-6890/3/6/00167
- Views 96
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