Catastrophic Anti-phospholipid Syndrome Presenting with Symmetrical Peripheral Gangrene
Journal Title: Journal of Advances in Medical and Pharmaceutical Sciences - Year 2016, Vol 9, Issue 1
Abstract
Introduction: Anti-phospholipid syndrome (APS) is an acquired auto-immune thrombophilia and is very rare in children presenting with skin manifestations. Case Report: A case of 12 years old female who presented to the Emergency with discoloration of arms and legs and later developed gangrene which then auto-amputated. Anti-cardiolipin antibodies were found to be positive and skin biopsy findings were consistent with APS. She was diagnosed with catastrophic anti-phospholipid syndrome. Anti- ds antibodies were found to be negative. Conclusion: Criteria for diagnosing APS in children should be developed as the adult APS diagnostic criteria doesn’t seem to apply on peadiatric patients. Prior studies too apply emphasis on this fact.
Authors and Affiliations
Ujala Zubair, Ahmad Faraz, Zarafshan Zubair
Keywords
Related Articles
- EP ID EP328462
- DOI 10.9734/JAMPS/2016/26577
- Views 78
- Downloads 0
Evaluation of Phytochemical and in vitro Antimicrobial Effects of Solanum lycopersicum Linn. (Tomato) on Oral Thrush and Human Cariogenic Pathogens
Aims: Study on the evaluation of phytochemical and antimicrobial effects of tomato Solanum lycopersicum (L.) on oral thrush and human cariogenic pathogens was designed to determine the antimicrobial effect of tomato extr...
Experimental Evaluation of Analgesic and Antioxidant Effects of Hydromethanolic Extract of Dioscorea dumetorum Tuber
Aims: The hydromethanolic extract of D. dumetorum was evaluated for antinociceptive and antioxidant activities to validate its uses in traditional medicine for these purposes. Methods: The antioxidant activity of D. dume...
Comparative Assessment of the Gastrointestinal Tolerability, Anti-inflammatory and Antipyretic Effects of Diclofenac, Ibuprofen and Nimesulide in White Albino Rats
Aim: NSAIDs is among the commonly used drug in the management of disease conditions. The study carried out comparative assessment of gastric tolerability, antipyrectic and anti inflammatory effect of diclofenac, ibuprofe...
Berberine Prevents Bone and Cartilage Destruction and Influences Cell Senescence in Experimental Arthritis
Background: Berberine (BB) is a protoberberine alkaloid with a wide spectrum of pharmacological activities considered to be a selective Janus kinase (Jak)3 inhibitor. Nevertheless, the mechanisms of berberine’s actions o...
Effect of Ethanolic Leaf Extract of Sarcocephalus latifolius on Some Biochemical Parameters in Alloxan Induced Diabetic Rats
This research project was carried out to investigate the biochemical effect of Sarcocephalus latifolius leaf extract in alloxan induced diabetic rats. The study was carried out for about 12 months in the department of Bi...