CD-56 IMMUNOREACTIVITY IN FOLLICULAR CELL DERIVED LESIONS OF THYROID
Journal Title: Journal of Evolution of Medical and Dental Sciences - Year 2018, Vol 7, Issue 17
Abstract
BACKGROUND The microscopic distinction between benign and malignant lesions by conventional histology is at times difficult. Diagnosis of papillary carcinoma is based on specific nuclear features however, focal presence of the same features in other follicular epithelial lesions make the distinction of papillary carcinoma thyroid from other lesions difficult. Morphologic overlap between follicular lesions especially the follicular variant of papillary carcinoma and FC is quite common. Cellular nodules may exhibit similar nuclear features like that of papillary carcinoma thyroid due to defects in processing, in which case, distinction between the two becomes difficult. Follicular thyroid lesions have in common many morphological features, which frankly put a burden on the pathologist while trying to make a diagnosis by H&E. The objective of this study is to evaluate the expression of CD56 in follicular cell derived lesions of thyroid. MATERIALS AND METHODS This is a descriptive study conducted on the thyroid specimens received in the Department of Pathology, Government Medical College, Kottayam with a histological diagnosis indicating follicular cell derived lesion during a period of 18 months (May 2016- October 2017). RESULTS Among the 40 cases in the study group, 9 cases were non-neoplastic; all of which were cellular nodules (22.5%). Of the 31 cases of thyroid neoplasms, 25 cases were Papillary carcinoma thyroid and its variants which included 4 cases of papillary microcarcinoma (10%), 6 cases (15%) were follicular variant and 1 case (2.5%) of diffuse sclerosing variant. Six cases were Follicular carcinoma (15%). CD56 showed a positive expression in 88.88% cases of non-neoplastic lesions, a negative expression in 96% cases of Papillary carcinoma and its variants and a positive expression in 66.66% cases of follicular carcinoma. CONCLUSION Based on the findings of the present study, CD56 may be considered as a relevant marker of papillary carcinoma-thyroid and its variants and is useful in distinguishing papillary carcinoma-thyroid and hyperplasia/follicular carcinoma
Authors and Affiliations
Elvin Merin Cherian, Priya P. V, Sankar S
Keywords
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- EP ID EP415126
- DOI 10.14260/jemds/2018/464
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