Cd10 as a Prognostic Stromal Marker in Breast Carcinoma
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2017, Vol 16, Issue 1
Abstract
Aims and objectives: to study the stromal expression of cd10 in breast carcinoma, relationship with certain prognostic factors like 1.age and 2.nottingham’s grade, to study the role of stroma in the pathogenesis of breast cancer. Materials and methods: a total of 75 cases of breast cancer were included in the study. Representative sections were taken and hematoxylin and eosin staining was done. Immunohistochemistry was performed with cd10. Stromal expression of cd10 (>10% stromal positivity was considered positive) in invasive breast carcinoma was noted and was statistically analyzed with different known prognostic markers of breast carcinoma. Results: stromal expression of cd10 was found to be significantly associated with increasing tumor grade (p = <0.0001). No correlation was found between cd10 overexpression and age of the patient. Conclusion: the stromal expression of cd10 as well as its intensity has significant correlation with higher histological grade(grade 3), no correlation between cd10 expression and age of the patient. There is wide expression of cd10 in desmoplastic stroma of breast carcinoma and negative immunoreactivity in stromal cells of normal breast.
Authors and Affiliations
Dr. c. arun prabhakaran, Dr. r. sathyalakshmi . , Dr. p. arunalatha .
Keywords
Related Articles
- EP ID EP589566
- DOI 10.9790/0853-160107119122
- Views 84
- Downloads 0
Study on types of facets on the superior articular surface of dried human calcanei at RIMS, Imphal
The calcaneus is a weight bearing tarsal bone of the proximal raw. It also forms the posterior pillar of the two longitudinal arches of the foot. Normally there are three facets for synovial joints between calcaneus and...
Study of hyponatremia as prognostic factor In acute ST elevation myocardial infarction (STEMI)
Hyponatremia has been shown to be a predictor of cardiovascular mortality among patients with heart failure and the same mechanism of neurohormonal activation is also acting in cases of STEMI1 Hence we aimed to investiga...
Effect of Cigarette Smoking on Heart Rate Variability in Health Adult Smokers in The Age of 20-60 Years
Background: Smoking has acute deleterious effects on the blood pressure and sympathetic tone, and it reduces the myocardial oxygen supply. HRV is recognized as an effective and noninvasive tool for evaluating autonomic n...
Clinical Profile and Upper Gastrointestinal Endoscopy Findings in Patients with Acid Peptic Disease at GSL Medical College and Hospital, Rajahmundry
Acid peptic disease is a collective term used to include many conditions such as gastro esophageal reflux disease(GERD), gastritis, duodenitis , esophageal ulcer, gastric ulcer, duodenal ulcer, Zollinger-Ellison syndrome...
Locking plates and locking screws for management of mandibular fractures.
Introduction: Assaults were common cause for mandibular and zygomatic complex fractures. When trauma is reported from large industry urban areas with high unemployment, lower facial trauma from alterations are more commo...