Cd10 as a Prognostic Stromal Marker in Breast Carcinoma
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2017, Vol 16, Issue 1
Abstract
Aims and objectives: to study the stromal expression of cd10 in breast carcinoma, relationship with certain prognostic factors like 1.age and 2.nottingham’s grade, to study the role of stroma in the pathogenesis of breast cancer. Materials and methods: a total of 75 cases of breast cancer were included in the study. Representative sections were taken and hematoxylin and eosin staining was done. Immunohistochemistry was performed with cd10. Stromal expression of cd10 (>10% stromal positivity was considered positive) in invasive breast carcinoma was noted and was statistically analyzed with different known prognostic markers of breast carcinoma. Results: stromal expression of cd10 was found to be significantly associated with increasing tumor grade (p = <0.0001). No correlation was found between cd10 overexpression and age of the patient. Conclusion: the stromal expression of cd10 as well as its intensity has significant correlation with higher histological grade(grade 3), no correlation between cd10 expression and age of the patient. There is wide expression of cd10 in desmoplastic stroma of breast carcinoma and negative immunoreactivity in stromal cells of normal breast.
Authors and Affiliations
Dr. c. arun prabhakaran, Dr. r. sathyalakshmi . , Dr. p. arunalatha .
Keywords
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