CD117 expression on blast cells in acute myeloid leukemia
Journal Title: Медичні перспективи - Year 2015, Vol 20, Issue 3
Abstract
The aim of the present work was to analyze the frequency of CD117 (c-KIT) antigen expression on the blast cells in acute myeloid leukemia (AML), evaluation of the presence of the relationship between the expression of the c-KIT and leukemia according to the FAB classification and definition of co-expression of the antigen CD117, antigens CD33 and CD34. The data of 47 patients with AML were diagnosed. M0 AML variant was established in 3 (6%) patients, M1 – in 2 (4%), M2 – in 9 (20%), M4 – in 22 (47%) and M5 – in 11 (23%). For immunophenotypic stu¬dies monoclonal antibodies (mAb) that detect antigens of anti-CD34, anti-CD33 and anti-CD117 (Becton Dickinson, USA) were used. The presence of the antigen CD117 was detected in 39 people, accounting for 83% of all surveyed. Antigen c-KIT was present in 48.117.0% cells on average: in all 3 cases – AML M0, in2 cases of AML M1, in 6 cases – AML M2, 20 of 22 cases – AML M4 and in 8 of 11 AML M5 cases. Average levels of CD117 in investigated leukemia cases statistically differed significantly (p=0.0067). Among 39 CD117- positive patients in 25 (53%) co-expression of CD117+/CD34+ was revealed. Expression of CD117+/CD34- was observed in 14 cases (30%), CD117-/CD34+ – in 4 cases (8,5%), CD117-/CD34- – in 4 cases (8.5%). CD34 had of 64% of cells of myeloid origin. A high positive correlation between expression of CD117 and CD34 (r=+0,5169) was determined, being statistically significant (p<0.0067). CD33 antigen was present on 81% of the studied cells. A weak negative correlation between expression of CD117 and CD33 (r=-0,2247), was revealed, being statistically significant (p>0,0067).
Authors and Affiliations
N. Goryainova , A. Gordienko , V. Kubarova
Keywords
Related Articles
- EP ID EP132916
- DOI -
- Views 83
- Downloads 0
Вплив лозартану на ультраструктурну морфологію формених елементів крові у хворих на цукровий діабет та артеріальну гіпертензію
Определены ультраструктурные изменения форменных элементов крови у пациентов с артериальной гипертонией 1-2-й степеней, у больных сахарным диабетом 2-го типа в фазе компенсации и субкомпенсации, а также у больных сахарны...
In commemoration of corresponding member of NAMS of Ukraine doctor of medical sciences, professor Olexiy Volodymyrovych Lyulko
Clinical case of community-aquaired pneumonia on the background of previously undiagnosed occupational pulmonary fibrosis. Is occupational history important?
Interstitial lung disease is a systemic concept, which is understood as a group of progressive diseases, characterized by non-infectious inflammation in the wall of the alveoli and interstitial lung tissue and may result...
Features of resistance of major pathogens of respiratory tract infections in Dnipropetrovsk region
According to the retrospective analysis of data obtained for the period of the last four years, the resistance level of major infectious agents (Strepto¬coccus pneumoniae, Hаemophilus influenzaе) to the most of commonly...
Эффективность гиполипидемической терапии и характер течения ИБС после стентирования коронарных артерий
Мета роботи: вивчити взаємозв’язок між досягненням цільових показників ліпідного обміну і частотою виникнення несприятливих серцево-судинних подій у хворих після успішного стентування коронарних артерій. Матеріали й мето...