CD34 as a marker of angiogenesis in breast cancer: A study of 74 cases with brief review of literature
Journal Title: International Journal of Allied Medical Sciences and Clinical Research - Year 2017, Vol 5, Issue 3
Abstract
CD34 was studied as a marker of angiogenesis in breast cancer. 74 cases of IDC were studied for this purpose. The mean microvessel density grade and the mean microvessel count per 400X field were determined for each case. Further, these 2 parameters were compared between node negative and node positive cases in order to determine whether increased angiogenesis would increase the chances of metastasis to lymph nodes. It was observed that cases with lymph node metastasis showed increased angiogenesis with a mean microvessel count and microvessel density grade of 45.6 and 2.91, respectively. In comparison, cases with absence of lymph node metastasis showed less angiogenesis and the mean microvessel count and microvessel density grade was 16.15 and 1.05 respectively. On statistical analysis, the difference between both the microvessel count and microvessel density grade for the two groups came out to be highly significant (p<0.001). Hence, increased angiogenesis was seen to lead to increased chances of metastasis to lymph nodes in our study
Authors and Affiliations
Azka Anees Khan
Keywords
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