CD34 Positive Pediatric T Lymphoblastic Leukemia: A Tertiary Care Centre Experience
Journal Title: Journal of Medical Science And clinical Research - Year 2017, Vol 5, Issue 7
Abstract
leukaemia (B ALL) especially in children. There are only a few published data about immunophenotype of T ALL in India. So we studied the immunophenotypic pattern of T ALL in children by flow cytometry and correlated it with clinical and pathological factors. Materials and Methods: 271 consecutive cases of paediatric acute leukaemias reported in the Regional Cancer Centre, Thiruvananthapuram, Kerala, were immunophenotyped by flow cytometry and clinicpathological analysis was done in all cases. The study period was from June 2009-June 2011. T ALL cases were followed up for two and a half years till the completion of treatment. Result: Among the 271 cases of myeloperoxidase negative acute leukaemia, 232 were B-ALL, 39 were TALL. Among 39 cases of T ALL, 25 cases (64%) were CD34 positive and 14(35.8%) were CD34 negative. Of the 25 CD34 positive cases, only 12 (48%) completed treatment compared to 10 out of 14(71%) CD34 negative cases. Conclusion: The occurrence of CD34 positivity in T ALL is high in children coming to our centre from different parts of Kerala which is in contrast to western studies. Even though T ALL is treated under high risk protocol, CD34 positive cases need special attention and they should undergo molecular studies to detect the bad prognostic factor.
Authors and Affiliations
Dr Sindhu Nair. P
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