CD4+ Cell Count, Lipid And Lipoprotein Levels In Hiv Patients On Drug Treatment
Journal Title: International Journal of HIV/AIDS and Research (IJHR) - Year 2017, Vol 4, Issue 1
Abstract
Background: Previous reports showed lack of consensus on the possible etiology of coronary artery disease (CAD) between HIV-treatment with highly active antiretroviral therapy (HAART) and HIV-infection in particular. The aim of this study was to find out correlations of HIV-treatment and HIV-infection with CAD risk. Method: One hundred and twenty (120) participants involving HIV-patients on treatment (n = 40), treatment-naïve (n = 40) and equal number of age- and sex-matched controls were enrolled. The total cholesterol, triglycerides and lipoprotein (HDL-C) were analyzed using spectrophotometry. The LDL-C was calculated using Friedewald equation, TC/HDL-C and LDL-C/HDL-C ratios were also calculated. The CD4+ cell count was determined using flow cytometry. Result: The mean plasma total cholesterol levels in patients’ groups on treatment and treatment-naïve were significantly reduced when compared with controls, but the mean triglyceride levels for both treatment and the treatment-naïve groups were significantly increased when compared with controls. However, HDL-C and LDL-C values for patients on HAART and the treatment-naive were significantly reduced when compared with controls respectively. The CAD risk predictors, LDL-c and TC/HDL-C ratio, were significantly increased in patients on HAART when compared with the treatment-naive. The mean CD4+ cell count in treatment-naive was significantly lowered against both groups for treatment and controls. Conclusion: In this present study, abnormal lipid profile was associated with both HIV-infection and HAART-treatment. However, TC/HDL-C ratio, the strong predictor of CAD events in metabolic disorder was markedly high in HAARTtreatment and the associated difference may threaten higher risk for cardiovascular disease (CVD) during treatment.
Authors and Affiliations
Adedokun A. Kamoru
Keywords
Related Articles
- EP ID EP325382
- DOI 10.19070/2379-1586-1700029
- Views 69
- Downloads 0
Perceptions Regarding HIV/AIDS and Risky Behaviours Among Prison Inmates in Southwest Region of Cameroon
Prisoners are at exceptional risk of infection with HIV because of the association of injection drug use, tattooing, sex between men and unprotected sexual intercourse with incarceration. This study described the percept...
Synthesis and Anti Hiv-1 Reverse Transcriptase Evaluation of A Series of N-Mono Substituted Thiourea Derivatives
Thirteen kinds of N-monosubstituted thioureas have been synthesized from various primary amines through three different methods. The chemical structures of all the compounds have been characterized by the various spectra...
Renal Disease in HIV: Practical Aspects for Nephrologists
Patients with HIV represents a unique and often seemingly daunting challenge for nephrologists, as these patients often have many multi-system issues, and are on a mix of medications that are not well known or often pres...
A Study on Knowledge, Attitude, Behaviour and Practice (KABP) towards HIV/AIDS in Manipur,India
Background: Since its first detection in Manipur in the early 1990’s among a group of injecting drug users, HIV/AIDS has spread rapidly into the general population. Manipur is now one of the six high HIV/AIDS prevalence...
Relationship between Presarcopenia and Trabecular Bone Score in HIV - Infected People
Objective: Antiretroviral therapy (ART) has transformed HIV-infection to a chronic disease. Nonetheless, since ART does not fully restore immune health, patients develop inflammation-associated complications considered t...