CD4 Change among HIV Patients on ART Regime, Switch Over from Nevirapine to Efavirenz: A Comparative Study
Journal Title: International Journal of Contemporary Medical Research - Year 2017, Vol 4, Issue 9
Abstract
Introduction: Annual incidence of HIV infection in India is about 1.16 lakh among adult population in 2014. This study has been conducted to compare immunological outcome and effect on liver function by either Nevirapine (NVP) containing regime that is ZLN (Zidovudine, Lamivudine, Nevirapine) or Efavirenz (EFV) containing regime that is TLE (Tenofovir, Lamivudine, Efavirenz). Material and Methods: The study was conducted at a tertiary care centre over 105 patients this study was an observational study.The patients were evenly matched and categorized in three groups, Group A (ZLN), Group B (TLE), Group C (ZLN to TLE) and these patients received three antiretroviral drug one of the drug was either nevirapine (NVP) or efavirenz (EFV). Patients were followed up for 6 months for any change in CD4 count. Result: All subjects (i.e. 105) were followed for 6 months. Initially base line CD4 count has significant difference among each group and the difference in CD4 count after 6 months of therapy was also significant. Rise in CD4 count seen in each group but significant rise (p value<0.05) in CD4 count seen among group B and C only i.e. who were taking TLE and or change their regime from ZLN to TLE respectively. The average rise in CD4 count was 18.2, 103.4, 108.6 ingroup A, B, C respectively. After 6 month of therapy there was a significant difference (p< 0.05) in CD4 count when all three groups were compared. Conclusion: The antiretroviral regimen containing EFV was associated with better immunological outcome, than NVP containing regimen
Authors and Affiliations
Manoj Kumar Mathur, Jeetam Singh Rajput
Keywords
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