CD4 lymphocyte response following anti-retroviral therapy in HIV/AIDS patients - A study in Osmania General Hospital
Journal Title: Journal of Medical and Allied Sciences - Year 2016, Vol 6, Issue 2
Abstract
The present study aimed at serial three year assessment of CD4 cell response after initiation of anti-retroviral therapy (ART) in patients with HIV/AIDS attending to Osmania General Hospital. It was a retrospective hospital based observational study. Data was collected over a period of 3 years from 2005 to 2007 in the ART Centre, Department of Medicine, Osmania General Hospital. We included 110 HIV/AIDS who were on ART. Serial monitoring of CD4 count was done and assessed. All patients were on ART as per National Aids Control Organisation (NACO) guidelines. Investigations included complete blood picture, serum creatinine, blood urea, serum electrolytes, liver function tests, sputum for acid fast bacilli, chest radiography, CD4 cell count and if required fine needle aspiration and biopsy, magnetic resonance imaging, computerized tomography, colonoscopy were also performed. The result of the present study shows increase in mean CD4 count by 128.78 cells/mm3 after 6 months of initiation of ART, 24.77 cells/mm3 after 1 year, 67.53 cells/mm3 after 2 years and 5.59 cells/mm3 after 3 years from the base line CD4 cell count. It certainly reveals the improvement in the CD4 count after ART initiation. Improvement in CD4 count was almost equal in both male and female and in all age groups. Mean CD4 cell count improved by 240.31 cells/mm3 in females and 220.54 cells/mm3 in males from the baseline after 3 years of treatment with ART. The present study clearly shows definite improvement in CD4 cell count after ART of more than 100% irrespective of age and sex. Regular intake of drugs will improve immunologic response. Therefore, strict adherence to ART and regular counselling sessions at ART centres should be stressed upon.
Authors and Affiliations
Nanyam Srinivasa Rao| Upgraded Department of General Medicine, Osmania General Hospital/Medical College, Afzalgunj, Hyderabad-500012, Telangana, India, Ravala Siddeswari| Upgraded Department of General Medicine, Osmania General Hospital/Medical College, Afzalgunj, Hyderabad-500012, Telangana, India, Budithi Sudarsi| Upgraded Department of General Medicine, Osmania General Hospital/Medical College, Afzalgunj, Hyderabad-500012, Telangana, India, Barla Suryanarayana| Upgraded Department of General Medicine, Osmania General Hospital/Medical College, Afzalgunj, Hyderabad-500012, Telangana, India, Challagali Prabhu Kumar| Upgraded Department of General Medicine, Osmania General Hospital/Medical College, Afzalgunj, Hyderabad-500012, Telangana, India, Thatikala Abhilash| Upgraded Department of General Medicine, Osmania General Hospital/Medical College, Afzalgunj, Hyderabad-500012, Telangana, India
Keywords
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- EP ID EP12746
- DOI 10.5455/jmas.215189
- Views 387
- Downloads 26
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