Cefpodoxime Proxetil and its By-Products: A Comparative Study as Per EP-7
Journal Title: LOJ Medical Sciences - Year 2018, Vol 1, Issue 2
Abstract
Cephalosporins are the highly used Broad-spectrum antibiotics, belong to β-lactam class. Cephalosporins resemble penicillin in that they have a β-lactam structure, but the five-member thiazolidine ring characteristic of the penicillin is replaced by a sixmember dihydrothiazine ring. The bactericidal action of beta lactam antibiotics is directly attributable to their ability to react with PBP’s. The research work relates to a by-products during process for the industrial manufacture of Cefpodoxime Proxetil. The drug is registered in USP and belongs to 3rd generation drug. It was discovered by Brotzu in fungus Cephalosporium Acremonium which produces a chemical which show antimicrobial activity. Abraham isolated the three fragmentation patterns of cefpodoxime proxetil. Data from this systematic study will help improve the safety and quality of cefpodoxime proxetil types of cephalosporin antibiotics cephalosporin P, cephalosporin N, cephalosporin C.7-ACA is widely used as the substrate for synthesizing cephalosporin antibiotics. Modification of the 7-ACA side-chains resulted in the development of useful antibiotic agents, and the first agent is Cephalothin (cefalotin) was launched by. Eli Lilly Company in 1964 There are many patents which gives the procedure of Synthesis of Cefpodoxime ProxetilStability of three Cefpodoxime proxetil products available in indian market at fridge temperatures (2-8 °C), room temperature (25 °C) and elevated temperature (42 °C). Flow properties, rheological and the physicochemical parameters of both powder and reconstituted powder were used to evaluate the stability of different brands of Cefpodoxime proxetil available in india. The powder of stability samples was eluted through a C18 column with formic acid-methanol-water as the mobile phase. In total, 15 impurities were characterized in commercial samples, including 7 known impurities and 8 new impurities. The structures of these unknown compounds were deduced via comparison.
Authors and Affiliations
Krishnasarma pathy
Keywords
Related Articles
- EP ID EP573372
- DOI 10.32474/LOJMS.2018.01.000110
- Views 47
- Downloads 0
How to Evaluate Pancreaticoduodenectomy Specimens after Pancreatic Surgery? A Review
Pancreaticoduodenectomy (Whipple procedure) is a complicated surgical procedure that is preferred in conditions such as malignancies and traumas of the pancreatic head, duodenum, bulb and choledoch or in case of pancreat...
Cefpodoxime Proxetil and its By-Products: A Comparative Study as Per EP-7
Cephalosporins are the highly used Broad-spectrum antibiotics, belong to β-lactam class. Cephalosporins resemble penicillin in that they have a β-lactam structure, but the five-member thiazolidine ring characteristic of...
The World Politics of Dominique Moisi
In his recent (2009) book, The Geopolitics of Emotion, D. Moisi, a French political scientist, took a still somewhat unusual approach; emotions can be causal in political relationships. The book argues indeed that they m...
Doctors should be paid more
In every country, a medical doctor is highly respected and usually paid double the average wage and often much more especially if they can be self-employed and charge the patients directly. Governments and insurance comp...
The Histopathological Changes after Neoadjuvant Theraphy for Rectal Carcinoma
Colorectal carcinomas are the third most common carcinomas in men and the second most common carcinomas in women. It has also been reported that deaths due to colorectal cancers account for...