Central effect of histamine in a rat model of acute trigeminal pain.
Journal Title: Pharmacological Reports - Year 2008, Vol 60, Issue 2
Abstract
In conscious rats implanted with an intracerebroventricular (icv) cannula, effect of icv injections of histamine, chlorpheniramine (H(1)-receptor antagonist) and ranitidine (H(2)-receptor blocker) was investigated in a rat model of acute trigeminal pain. Acute trigeminal pain was induced by putting a drop of 5 M NaCl solution on the corneal surface of the eye and the numbers of eye wipes were counted during the first 30 s. Histamine (20, 40 mug) and chlorpheniramine (80 mug) significantly decreased the numbers of eye wipes. Ranitidine alone had no effect. Pretreatment with chlorpheniramine did not change the histamine-induced analgesia, whereas the histamine effect on pain was inhibited with ranitidine pretreatment. These results indicate that the brain histamine, through central H(2) receptors, may be involved in the modulation of the acute trigeminal pain in rats.
Authors and Affiliations
Esmaeal Tamaddonfard, Emad Khalilzadeh, Nasrin Hamzeh-Gooshchi, Sona Seiednejhad-Yamchi
Keywords
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