Central interaction of ascorbic acid and D2 dopamine receptors on spatial learning and memory in adult male rats
Journal Title: Iranian Journal of Veterinary Science and Technology (IJVST) - Year 2014, Vol 6, Issue 1
Abstract
Previous studies had reported that extracellular levels of ascorbic acid have modulatory effects on dopamine receptors. Both ascorbic acid and dopamine receptor have an important role in learning and memory processes. However, the central interaction between ascorbic acid and dopamine D2 receptor on spatial learning and memory has not yet been elucidated. All experiments were carried out on male Wistar rats. Animals were subjected to 5 days of training in the Morris water maze (MWM) task; 4 days with an invisible platform to test special learning and the 5th day with a visible platform to test motivation and sensorimotor coordination. The data showed that ascorbic acid (25 µg, i.c.v.) could improve spatial learning and memory indices. Administration of bromocriptine, a D2 agonist, increased the effect of ascorbic acid, while treatment with the selective D2 antagonist sulpiride resulted in prevention of the ascorbate-induced memory consolidation. These results indicate that dopamine D2 receptors may be involved in ascorbic acid-induced learning and memory impairment.
Authors and Affiliations
Sima Nasri, Mehri Bahaaddini, mehdi abbasnejad, Saeed Esmaeili-Mahani, Ramin Raoof
Keywords
Related Articles
- EP ID EP722479
- DOI -
- Views 50
- Downloads 1
Histopathologic report of infestation by Centrocestus formosanus in Iranian grass carp and common carp
Flukes cause severe and lethal diseases in various animals comprising fish. Both adult and larval stages are found in fish. Centrocestiasis is an infection of the fish gills by heterophyid trematode Centrocestus formosan...
Successful treatment of a subcutaneous axillary abscess due to Staphylococcus lentus in a rabbit
A 2-year-old, female, crossbred pet rabbit was found to have a subcutaneous axillary abscess from which Staphylococcus lentus was the sole isolate. The S. lentus - an indigenous bacterium in rabbit saliva - probably was...
Severe subcutaneous, muscular and visceral coenurosis in a goat
Coenurosis (gid or sturdy) is a zoonotic disease that is caused by Taenia multiceps metacestode. It is common in small ruminants. The cysts in sheep are more cerebral, while are noncerebral in goats. Coenurosis decreases...
Laxative effect of bitter almond (Amygdalus communis var. amara)
Thepossible laxative and prokinetic effects of bitter almond were studied: 1- two groups of 7 rats were gavaged with ethanol extract of bitter almond (500mg/kg) or placebo and the number of feces, fecal weight and its pe...
Lead poisoning in cattle associated with batteries recycling: High lead levels in milk of nonsymptomatic exposed cattle
Lead poisoning associated to residuals of batteries recycling was diagnosed in a small herd of Holstein cattle. In this outbreak, 10 animals showed clinical signs of lead poisoning, 5 dead and others saved after chelatin...