Central Pontine Myelinolysis Associated with Cyclosporine in a Patient with NK Cell Leukaemia after Hematopoietic Stem Cell Transplantation
Journal Title: International Journal of Stem Cell Research and Transplantation (IJST) - Year 2016, Vol 4, Issue 1
Abstract
Central pontine myelinolysis (CPM) has been described as a rare complication of liver transplantation. Cases in allogeneic hematopoietic stem cell transplant are less reported. We present a patient with NK cell leukaemia who underwent allogeneic hematopoietic stem cell transplant and had progressive altered mental status and neurological deterioration. Clinical and radiological findings were consistent with CPM. The patient had hepatic impairment and was on cyclosporine at the time of diagnosis of CPM, both are common risk factors for development of CPM in the post-transplant setting. Patient was managed in the intensive care unit. A trial of corticosteroids was given and immunosuppressive agent was switched from cyclosporine to sirolimus. Patient regained full neurological function from this CPM episode.
Authors and Affiliations
Cheong May Anne
Keywords
Related Articles
- EP ID EP197484
- DOI 10.19070/2328-3548-1600024
- Views 86
- Downloads 0
Xenotransplantation for Renal Failure Patients: Evolution of Strategies
Xenotransplantation for Renal Failure Patients: Evolution of Strategies
Neonatal Eye Defects and Stem Cell Therapeutics
Present review aims to describe various neonatal eye defects and its stem cell therapeutics. This article attempts to highlight common causes of visual impairment in infants and present the recent approaches used for res...
Umbilical Cord Blood Transplantation: Clinical Challenges
Umbilical cord blood transplantation (UCBT) is becoming a salvage treatment in lieu of bone marrow or peripheral blood stem cell transplantation in patients with hematological disorders who lack human leucocyte antigen (...
Generation and characterization of induced pluripotent stem cells in domestic Asian water buffalo (Bubalus bubalis)
Induced pluripotent stem cells (iPSCs) have numerous applications in livestock to improve production traits, disease resistance, biopharming, conservation of germplasm, disease modeling, regenerative medicine etc. Here,...
ISW for the Treatment of Adult Angle Class I Crowding with Acceptable Lateral Profile Case
This article describes a 34-year-old adult female with chief complaint of poor dental alignment. She presented with Angle Class I crowding with acceptable lateral profile and had been treated with a non-extraction approa...