Cerebral cavernous malformations: epidemiological, clinical and diagnostic imaging aspects
Journal Title: Progress in Health Sciences - Year 2018, Vol 8, Issue 2
Abstract
<b>Introduction:</b> Cerebral cavernous malformations (CCMs) are one of the most common vascular malformations of the central nervous system. Symptoms of CCMs are not typical; the disease can be asymptomatic or be manifested by a wide range of neurological symptoms.<br/><br/><b>Purpose:</b> To evaluate chosen epidemiologic and clinical issues as well as advanced imaging diagnostics of CCMs in computed tomography and magnetic resonance imaging.<br/><br/><b>Materials and methods:</b> The study was based on retrospective analysis of CT and MRI examinations from the 5 years period. The analysis covered 61 persons, 29 males, and 32 females. The CCMs were diagnosed based on MRI examination in 43 patients and CT in 13 patients.<br/><br/><b>Results:</b> The rate of CCMs occurrence in own material was 0.2%. Single lesions were present in 90.2%, while multiple in 9.8% of cases. Supratentorial CCMs were observed in 77% of cases whereas subtentorial in 23%. Mean size of CCMs in the supra- and subtentorial area equaled 10.6±6.3 and 15.1±5.8 mm, respectively (p<0.05). Clinical symptoms occurred in 65.8% of patients, most frequently in patients with CCMs above 5 mm or with subtentorial lesions. All CCMs were hyperdense in CT images, with calcifications in 13.1%. In MRI, malformations showed diverse intensity of the central part with peripheral low-intensity rim of hemosiderine deposits in T2-weighted images.<br/><br/><b>Conclusions:</b> The clinical symptoms occur in most cases of CCMs. These patients require periodic follow-up MRI examinations, specifically those with haemorrhagic incidents or epileptic seizures, with large size or subtentorial CCMs.<br/><br/>
Authors and Affiliations
I. Czekalska, Z. Tyrakowska-Dadełło, P. Werel, E. Tarasów
Keywords
Related Articles
- EP ID EP430355
- DOI 10.5604/01.3001.0012.8316
- Views 91
- Downloads 0
Lower limb oedema in vascular disease
Introduction: Lower limb oedema is a significant problem in vascular diseases. Due to the localization, it greatly hampers normal mobility affecting quality of life. Purpose: To evaluate the frequency of lower li...
Skin changes in the neck and selenium content in patients with thyroid diseases
Purpose: Occurrence of skin changes, in the form of discolouration on neck and in form of a so-called ”thyroid shadow”, was observed in patients with: Hashimoto’s disease, Graves´ disease, struma nodosa euthyrotica...
Epidemiology of abdominal aortic aneurysm
Introduction: Abdominal aortic aneurysm is a localized widening, located below the renal arteries. The exact etiology is not fully understood. Probably the main role in the formation of abdominal aortic aneurysm plays a...
Extrajudicial ways of compensating for medical damage in Poland
On January 1, 2012, an amendment to the act on Patient Rights and the Ombudsman for Patient Rights was passed. The amendment introduced the concept of a medical event, defining legal bases for voivodeship commissions to...
Effect of increasing graded doses of formaldehyde on human embryonic kidney cells
Purpose: In the present study, we aimed to identify the effect of three increasing doses of most widely preservative, formaldehyde (FA) on the urinary system using human embryonic kidney cells (HEK-293) in vitro. Materia...