Cerebroprotein Hydrolysate in the Management of Acute Spinal Cord Injury
Journal Title: Scholars Journal of Applied Medical Sciences - Year 2018, Vol 6, Issue 4
Abstract
Spinal cord injury is an extremely serious and world most disasterous type of physical trauma that can have a lasting and significant impact on most aspects of daily life leading to a grievous clinical situation, for which there is no effective treatment till today. Anyone who survived from such injury used to live with morbidily and other complication. In case of acute spinal cord injury methylprednisolone is a standard treatment option. It can result in Tetraplegia /quadriplegia, paraplegia and other lifetime disabilities. Cerebroproteinhydrolysate a neuropeptide synthetic preparation having neurotropic and neuroprotective role, being successfully used in the treatment of Alzheimers disease, in acute cerebrovascular strokes, traumatic brain injury with proven benefits. Few studies support its role in spinal cord injury benefits. Cerebroproteinhydrolysate is a mixture of different neurotrophic factors such as BDNF, GDNF and NGF used to treat the normal SCI our experience showed that Cerebroprotein hydrolysate resulted in good neuroprotection. This prospective study was conducted in the neurosurgery unit of surgery department in Gandhi medical college &Associated Hamidia Hospital Bhopal in this study 120 patients of acute spinal cord injury were enrolled who reported in the emergency ward within 8 hours of injury. We assessed the efficacy and safety of cerebroproteinhydrolysate in the treatment of traumatic acute spinal cord injury and its outcome. Cerebroproteinhydrolysate treated group was compared to the conventional therapy (controlled) group. There was a statistically significant (p value=0.001) seen in improvement in terms of functional outcome in patients treated with cerebroproteinhydrolysate These patients have significant motor and partial sensory recovery including the sensations of touch, pressure, vibration and pain: from A to B score on ASIA scale. Initial prehospital management of traumatic acute spinal cord injury is crucial for the morbidity and mortality following acute SCI. For a long time no proper and promising treatment for SCI was available. This study shows that cerebroprotienhydrolaste has beneficial outcomes as immediate neuroprotective therapy and ensuring the spinal cord perfusion pressure augmentation has no complications and the results are promising. Our results suggest that patients with traumatic acute spinal cord injuries when treated with cerebroproteinhydrolysate are benefitted significantly in regards to functional outcome and it can be safely used. Though a large size randomized control trials are required to authenticate its potential benefits.
Authors and Affiliations
Dr. I. D. Chaurasia, Dr Puspendra Gahlot, Dr. Mahim Koshariya, Dr. Arvind Rai, Dr. M. C. Songra
Keywords
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