Cerebrospinal Fluid C-Reactive Protein and Adenosine Deaminase Levels in the Differential Diagnosis of Meningitis in Adults
Journal Title: International Journal of Contemporary Medical Research - Year 2018, Vol 5, Issue 3
Abstract
Introduction: Acute infections of the Central Nervous System like Meningitis and Encephalitis, need to be diagnosed promptly because early institution of treatment would not only be life saving but also reduce consequent neurological impairment. This study was aimed to assess the signicance of estimation of Cerebrospinal Fluid C-Reactive Protein and Adenosine Deaminase levels in differential diagnosis of meningitis in adults. Material and Methods: This study was carried out in the department of Medicine at Shri Sayaji General hospital, where we enrolled 50 patients presenting with symptoms and signs of meningits. Routine and microscopic examination of of CSF was done, alongwith CSF ADA and CRP. Results: Out of total 50 patients, 23 had tubercular meningitis, 6 had pyogenic and 21 had viral meningitis.The mean ADA activity in the tubercular group was significantly higher than in other groups. The CRP levels were significantly higher in pyogenic meningitis as compared to the other two groups. Conclusion: High CSF ADA and CSF CRP can be used to differentiate between tubercular, pyogenic and viral meningitis. High ADA levels are suggestive of tubercular meningitis High CSF CRP levels are suggestive of Pyogenic meningitis, both of which are reduced in viral meningitis.
Authors and Affiliations
Jaya M Pathak, Smit Seth, Zeal Kishor Thakkar, Charoo Chandrashekhar Iyer, Kesar Vinodbhai Prajapati
Keywords
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