CERVICAL CANCER: GENETIC FACTOR- CONSEQUENCES AND COMPLICATIONS
Journal Title: Indian Obstetrics & Gynaecology - Year 2017, Vol 7, Issue 1
Abstract
Cervical cancer is the third most common cancer of women. This carcinoma is caused by Human Papillomavirus (HPV), acquired as a sexually transmitted infection; HPV 16 is most carcinogenic among all HPV variants. HPV infection depends on certain risk factors like demographic profile, ethnicity, parity, high risk sexual behavior, hormonal intake, immunocompromised status, tobacco and smoking. Many host factors also contribute in the persistence and progression of disease, which include genetic (p53 gene polymorphism, loss of heterozygosity and microsatellite instability), epigenetic, nutritional and host immune factors.
Authors and Affiliations
Dr. Mukta Agarwal, Dr. Ajit Saxena
Keywords
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