CERVICAL INTRAEPITHELIAL LESIONS IN HIV AND NON-HIV WOMEN ATTENDING ART CENTRE AND GYNAEC OPD IN RAICHUR INSTITUTE OF MEDICAL SCIENCES, RAICHUR
Journal Title: Journal of Evidence Based Medicine and Healthcare - Year 2015, Vol 2, Issue 36
Abstract
Cancer cervix is the second most common cancer in women. Infection with HPV has been implicated in pre-cancerous squamous intraepithelial lesions and their progression to cervical cancer. The risk of infection with HPV is augmented in the presence of HIV infection. Hence we conducted this study to assess the difference in occurrence of cervical intraepithelial lesions in HIV positive and HIV-negative patients. METHODS:100 women attending the ART centre and gynaec OPD were chosen, out of which, about half were HIV positive and the other half were HIV negative. Each of them underwent Pap smear examination signing a written consent. The smears were sent to pathologists for evaluation. After cytological examination, the cervical squamous intraepithelial lesions were classified based on their cytomorphological features. RESULTS: In the HIV-negative category, the prevalence of squamous cell abnormality in the age group 31-40 was 14.3% and in the age group 41-50 was 20%. In the HIV positive category, increased incidence of squamous cell abnormality was found in the age group 31-40(26.7%). This indicates that squamous cell abnormality in the HIV positive category had high prevalence in the younger age group. CONCLUSION: in conclusion, HIV infection appears to alter the spectrum of HPV infection and its further development into precancerous lesion and invasive cancer. We also noted that the intraepithelial lesions tend to occur at an early age in HIV positive women. This may be attributed to any alterations in the local response of the genital tract induced by HIV or due to the paucity of cell mediated immunity.Hence high priority must be given for early screening process to detect the cervical lesions at the earliest among HIV positive womenin order to prevent them from developing into invasive cancer.
Authors and Affiliations
Inder Raj Itagi, Hrudya Hrudya
Keywords
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- EP ID EP232668
- DOI 10.18410/jebmh/2015/771
- Views 68
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