CHANGES IN CENTRAL CORNEAL THICKNESS IN DIABETES MELLITUS PATIENTS
Journal Title: Journal of Evidence Based Medicine and Healthcare - Year 2018, Vol 5, Issue 26
Abstract
BACKGROUND India has emerged as the diabetes capital of the world. A large percentage of these patients have metabolically uncontrolled Diabetes Mellitus. High glucose level has deleterious effect on corneal endothelial health due to various mechanisms and is associated with changes in central corneal thickness (CCT). We intend to compare the CCT of established DM patients with normal population and correlate its impact with increasing diabetic population. The objectives of the study were to evaluate the effect of diabetes mellitus on central corneal thickness (CCT) by comparing the CCT of diabetic and non-diabetic patients and association of CCT with duration of diabetes mellitus. MATERIALS AND METHODS The study group was composed of 53 non-diabetic (29 male and 24 female) and 50 diabetic subjects (15 male and 35 female). Among the diabetic subjects, 27 out of 50 had diabetes of less than 10 years of duration and 23 had diabetes for more than 10 years. The CCT assessment was done for 105 eyes of 53 non-diabetic subjects and 100 eyes of 50 diabetic subjects with Sonomed Pacscan Plus, an ultrasound pachymeter, in the multiple reading single point mode. Each CCT considered in study was the average of 5 readings with standard deviation less than 0.003mm. RESULTS The statistical difference in the CCT between diabetic (524.264±29.21 microns) and non-diabetic (513.228±30.81 microns) group was significant (two-tailed P value is 0.0167 – Mann-Whitney test). When the CCT of non-diabetic group was compared with those with diabetes of less than 10 years duration, it was not significant (p value 0.13); and those with diabetes of more than 10 years duration, the difference was significant (p value 0.0216). The statistical difference between male and female in either group was not significant. CONCLUSION With rapid increase in number of diabetic patients, it is necessary to evaluate its effect on cornea, especially in the pre-operative work-up. A thickened cornea in diabetic patients needs to be evaluated for its functional and morphological characteristics.
Authors and Affiliations
Mamta Singh, Abhishek Anand, Bibhuti Prassan Sinha, Nagendra Prasad, Sujeet Mishra
Keywords
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- EP ID EP567151
- DOI 10.18410/jebmh/2018/412
- Views 73
- Downloads 0
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