Changes in integral indicators of the functional state of experimental animals with the long-term introduction of cadmium chloride and nanoparticles of sulfide cadmium of different sizes
Journal Title: Український журнал сучасних проблем токсикології - Year 2017, Vol 79, Issue 3
Abstract
The purpose of the study was a comparative assessment of the integral indicators of the functional state of experimental animals under conditions of prolonged exposure to cadmium chloride and nanoparticles (NP) of cadmium sulfide of different sizes. Materials and Methods. The studies were carried out on male rats of the mature age of the Wistar line weighing 160–180 grams, which were injected intraperitoneally with cadmium chloride (CdCl) and cadmium sulfide (CdS) nanoparticles with a size 4–6 nm and 9–11 nm in a dose of 0,08 mg/kg/day in terms of cadmium. The body weight was measured weekly. The weight of the internal organs and the muscular endurance measured by the duration of retention time on the pole was evaluated after 30 injections (1,5 months), after 60 injections (3 months), and after cessation of introduction. Results. CdCl2 and NP CdS caused a decrease in the average body weight and body weight gain in comparison with control animals. NP CdS caused a mentioned decrease earlier than CdCl2, but under the influence of CdCl2, these changes were more pronounced. In animals, after the introduction of cadmium compounds, were observed an increase in the relative mass of the brain, liver, spleen, thymus, a decrease in lung mass. There were also observed an increase in the relative mass of the heart and kidney after 30 and 60 injections and their decrease in the post-exposure period. The greatest changes in the weight of the organs where caused by CdCl2, while the smallest ones where caused by NP CdS with the size of 9–11 nm. Reduction of muscular endurance of rats after 30 injections was most pronounced when exposed to NP CdS in size of 4–6 nm. But, in a period after 60 injections and in the post-exposure period, the reduction of muscular endurance was most pronounced with CdCl2 exposure.
Authors and Affiliations
O. L. Apykhtina
Науковий діапазон вченого. (До 80-річчя доктора біологічних наук В. Д. Чміля)
До 80-річчя доктора біологічних наук В.Д. Чміля Іде людина, живе людина — і сонцем світиться вона. У неповторності єдина і у повторності одна. Саме такі слова спадають на думку під час спілкування з Віталієм Даниловичем...
Hygienic assessment of toxicodynamics peculiarities and mechanism of action of oxyacetamide class herbicide (flufenacet) on homoiotherms and human body
Analysis of literature data regarding toxic properties of a new oxyacetamide class herbicide, flufenacet, in acute, subchronic, and chronic experiments among different species of animals was performed. It was established...
Отсутствие модифицирующего эффекта тербутилазина на канцерогенез молочной железы, индуцированный полициклическим углеводородом — 7,12 диметилбензантраценом у крыс
Цель работы — изучить возможность промоторного эффекта Тербутилазина на канцерогенез молочной железы, индуцированный полициклическим углеводородом 7,12 дибензантраценом (ДМБА) у крыс-самок Wistar Han. Материалы и методы....
Methodological Aspects of the Problem of Ensuring the Chemical Safety of Paint and Varnish Materials in the European Union Countries and Ukraine
Objective. Conduct a comparative analysis of legislative decisions, legal framework, methodology, standards in force in the EU and Ukraine, which are aimed at implementing management solutions in the system of ecologizin...
До 75-річчя від дня народження В. І. Медведєва
21 вересня 2017 року виповнилося 75 років від дня народження знаного науковця у галузі гігієни застосування пестицидів і полімерів, а також з проблем діоксинів та біфенілів відділу «Інститут екогігієни і токсикології пес...