Changes in Lipid Profile and Fasting Blood Glucose in Protease Inhibitor Exposed HIV/AIDS Patients
Journal Title: Indian Journal of Nutrition - Year 2016, Vol 3, Issue 2
Abstract
Background: The national second-line Anti retroviral Therapy (ART) programme was started in Kolkata, India in December 2008. It included a combination of Tenofovir, Lamivudine and Ritonavir-boosted Lopinavir ± Zidovudine. Dyslipidaemia and increased fasting blood sugar (FBS) often complicate protease inhibitor-containing ART. Thus a prospective study was designed to observe the above changes. Methods: The data of 50 patients, on protease inhibitor for one year, were analyzed. Body Mass Index (BMI), grip strength (GS), Triceps skin fold (TSF), 24 hour dietary recall, serum triglyceride (TG), total cholesterol (TC), HDL, LDL, VLDL and FBS were estimated for all patients at baseline, 6 months and after one year. Results: There was a significant increase in TG, TC and VLDL levels at 1 year as compared to baseline (p=0.013, 0.00 and 0.00 respectively) whereas LDL significantly increased at 6 months only (p=0.029). HDL decreased significantly at 6 months (p=0.019). TSF significantly decreased both at 6 and 12 months (p=0.00 and 0.00 respectively). The BMI and GS showed a significant increase at both 6 months (p=0.009, 0.000 respectively) and 1 year (p=0.002 and 0.00 respectively). Four patients with normal baseline FBG and one with impaired fasting glucose progressed to overt diabetes (FBG ≥ 124 mg/dl) at 12 months. No significant change was noted in energy and protein intake of patients. Conclusion: There is an increased incidence of dyslipidaemia and unmasking of diabetes related to protease inhibitor in this cohort. There has been an improvement in nutritional status as shown by BMI and GS.
Authors and Affiliations
Ananya Bhowmik
Keywords
Related Articles
- EP ID EP332132
- DOI -
- Views 172
- Downloads 0
Community Perception and Acceptance of Micronutrient Fortified Complementary Food in Integrated Child Development Services (ICDS), Gujarat, India
Background: Fortification of complementary food is seen as a potent intervention to address child malnutrition. Government of Gujarat introduced Balbhog; an extruded fortified blended “a pre-cooked, cereal-based suppleme...
Type 1 diabetes and management of its emergencies in hospital: A Case Report
Type 1 diabetes is a disorder characterized by hyperglycemia either due to insufficient or ineffective insulin availability. There are increasing incidences of type 1 diabetes seen amongst children with three new cases o...
Incorporation of Ricinodendron heudolotti Meal into Blends of Wheat and Precooked Taro Flour for Production of Nutrient Dense Biscuits
Protein energy malnutrition remains the biggest nutritional problem in children under five years in developing countries. Provision of nutritious snack foods to children could go a long way in resolving this problem. Com...
Effect of Protein Energy Malnutrition on the Diarrheal Electrolyte Imbalance in Children of Chittagong Region, Bangladesh
The study was carried out to identify the risk factors involved in the development of Protein Energy Malnutrition and its effect on the diarrheal electrolyte imbalance in Bangladeshi children. Among a 100 protein energy...
Factors Influencing Perception of Climate Variability and Change among Smallholder Farmers in Swaziland
Climate change is a reality and has been confirmed by global scientific consensus to affect the productivity of agricultural ecosystems. Farmers perceive climate change differently and their perception of climate variabl...