Changes in pattern of Erythrocyte Sedimentation Rate and C-Reactive Protein following major elective orthopaedic surgeries
Journal Title: Asian Pacific Journal of Health Sciences - Year 2017, Vol 4, Issue 1
Abstract
Background and Objectives: Major surgeries are associated with various changes in the neuroendocrine and inflammatory cytokine system of the body. Most of these surgeries are performed with expensive implants and prostheses made of metals and their alloys. These metals are foreign bodies which when infected can lead to a disastrous outcome. Consequently, concerted effort is being made through the use of Erythrocyte Sedimentation Rate (ESR), C-reactive Proteins (CRP), and other acute phase proteins as a screening tool for early detection of deep surgical wound infections. The aim of this study was to determine the pattern of changes of ESR and CRP following major elective orthopaedic surgeries. Patients and Methods: This is a cross sectional study carried out over a period of six months. All patients that had major surgery within the period were noted and followed up. ESR and CRP levels were checked pre-operatively on day 0 and post-operatively on days 2, 4, 7 10, 14 and 42 using the modified Westergreen method and the High Sensitivity (HS) ELISA technique respectively. Results: The result showed a steep rise in both parameters (more than 300% constitutive levels) within 2 days post-operatively. The peak value for the mean serum CRP level was attained on day 4 post operatively with normalization to its pre-operative serum level on day 42 (P = 0.543), while the mean serum ESR reached its peak on day 7 and remained significantly higher than its pre-operative mean serum level even on day 42 post operatively (P = 0.003).Conclusion: ESR and CRP are both useful acute phase proteins for monitoring early post operative complications like surgical wound infections.
Authors and Affiliations
Onyekwelu K C
Keywords
Related Articles
- EP ID EP525316
- DOI 10.21276/apjhs.2017.4.1.31
- Views 153
- Downloads 0
Ovarian ectopic pregnancy- a report of 2 cases and review of literature
Ovarian pregnancy is a rare form of ectopic pregnancy accounting upto .3-3% of all non tubal ectopics. Even though the incidence of ovarian ectopic pregnancies is on a rise attributable to recent advancements in the fiel...
Negative pressure assisted dressings: a game changer in wound care?
Background: Wounds and their management is the cardinal groundwork for a surgical practice. Wound management has been an ever evolving field. The methods we employ currently are nowhere close to the time of inception of...
A study of prevalence of anemia by sociodemographic, clinical, and laboratory characteristics among HIV-positive patients
Anemia in HIV-infected patients can have serious implications, which vary from functional and quality of life decrements to an association with disease progression and decreased survival. As anemia burden on morbidity an...
Frequency and antibiogram of Acinetobacter species isolated from various clinical samples in a tertiary care hospital
Background: Acinetobacter species have emerged as opportunistic pathogens and can cause a wide range of healthcare associated infections like ventilator associated pneumonia, meningitis, and bacteremia, urinary tract inf...
A study on patient compliance and acute toxicity in the management of head and neck cancers treated with concurrent weekly cisplatin and radiotherapy
Head and neck cancer is one of the ten most common cancers in the World constituting 15% of all malignancies. Head & Neck cancers rank 3rd in developing countries.In the prementioned context the current study is aimed at...