Changes in prostaglandin levels in the blood serum of patients with gastroesophageal reflux disease on the background of type 2 diabetes mellitus
Journal Title: Гастроентерологія - Year 2018, Vol 52, Issue 3
Abstract
Background. Digestive organ damage in patients with diabetes mellitus (DM) is based on several mechanisms: autonomic nervous system dysfunction, angiopathy, dysregulation of secretion and inactivation of hormones and increments. The purpose was to study the features of changes in prostaglandin (Pg) levels (I2 and F2α) in the blood serum of patients with gastroesophageal reflux disease (GERD) on the background of type 2 DM depending on the body mass index violation. Materials and methods. The study involved 54 patients with type 2 DM and GERD (group I). The comparison group included 22 patients with GERD (group II). The patients had their blood serum examined and indicators of Pg F2α and 6-keto-prostaglandin F1α (blood prostacyclin — Pg I2) determined. Results. Increased levels of prostaglandins in both groups of patients were detected, but more significant changes were observed in group I. Attention is called to a more significant increase in Pg I2 concentration compared with Pg F2α, especially in patients with GERD on the background of type 2 DM (3.4 times compared with 2.1 times in group I). Patients with GERD revealed the increased levels of Pg I2 by 2.2 times, while Pg F2α is only 1.6 times higher. In the combination of several pathological states (type 2 DM, GERD, increased body mass index), there is a more significant increase in the concentration of prostacyclin, which also depends on the duration of the disease. Conclusions. In patients with GERD, an increase in the levels of prostaglandins F2α and I2 in the blood serum has been detected. The combination of GERD and type 2 DM is accompanied by a more significant increase in the concentration of prostaglandins, especially Pg I2, in the blood serum. The correlation was established between the duration of type 2 DM mellitus, excessive body weight and the dynamics of Pg I2 level in the blood serum of patients with GERD on the background of type 2 diabetes mellitus.
Authors and Affiliations
Ye. S. Sirchak, M. P. Stan
Keywords
Related Articles
- EP ID EP388560
- DOI 10.22141/2308-2097.52.3.2018.141840
- Views 54
- Downloads 0
Chronic inflammatory bowel diseases: epidemiological features in Ukraine
Background. The number of registered patients with inflammatory bowel diseases (IBD) that is characterized by systemic manifestations and polymorbidal course is increasing nowadays. IBD, which include ulcerative colitis...
The Role of Buccal Epithelial Cells Properties to Adhesion of Candida albicans and Influence on It of Regulatory Cytokines During Infectious Process in Patients with Candidiasis of the Mucosa of the Upper Digestive Tract
The role of buccal epithelial cells in candidiasis development and the interrelation with peculiarities of cytokine balance in patients with candidiasis of the upper digestive tract continues to be studied today. The aim...
Insulin Resistance, Its Role in the Development of Nonalcoholic Fatty Liver Disease in Patients with Metabolic Syndrome, Ways of Correction
The article presents data on the role of the liver in carbohydrate and lipid metabolism, describes glucose metabolism features in insulin resistance and the role of glucokinase pathways of glucose uptake in the hepatocyt...
Diagnostics and Correction of Indigestion in a Practice of Family Physician
The results of the study of air-ions in 310 patients with combined pathology of digestive organs are considered in this article. The data about a new non-invasive method of the diagnostics and individual integrated treat...
The Epidemiologic Peculiarities of Inflammatory Bowel Diseases According To Data from State Institution «Institute of Gastroenterology of National Academy of Medical Sciences of Ukraine»
A retrospective analysis of case histories of 843 patients with ulcerative colitis and 222 — with Crohn’s disease who were treated at the State Institution «Institute of Gastroenterology of National Academy of Medical Sc...