Changes in Some Pharmacokinetics Parameters of Chloroquine by Gnetum Africana
Journal Title: Macedonian Journal of Medical Sciences (MJMS) - Year 2012, Vol 5, Issue 3
Abstract
Effect of Gnetum africana on the pharmacokinetic parameters of chloroquine was investigated. Chloroquine phosphate (200 mg/Kg) was concurrently administered to overnight fasted albino rats. Blood samples were collected 15, 30, 60, 120, 240 and 480 minutes after administration through cardiac puncture. Serum concentration of chloroquine was evaluated spectrophotometrically. The results indicated that the extract significantly decreased Cmax (9.17%), Ka (3.06%), Ke (45.38%), Cl(48.46%) and AUC (0-8) (16.90%). The extract also increased the values of t1/2 (83.11%), tmax (100.00%). The LD50 of the extract was 5.25 g/Kg. Phytochemical screening revealed the presence of steroids, tannins, flavonoids and traces of phlobatanins and alkaloids. Proximate and elemental analyses showed that the plant contained Sodium (26.37 + 0.01ppm), Potassium (32.84 + 0.02 ppm), Copper (0.01 + 0.00 ppm), Calcium (6.53 + 0.01ppm), Magnesium (7.58+ 0.02 ppm), Iron (2.01 + 0.02 ppm), Zinc (0.93 + 0.03 ppm), Lead (0.02 + 0.01 ppm), Moisture (10.90 + 0.91 mg/100 g), Crude protein (15.31 + 1.12 mg/100g), Crude fibre (4.20 + 0.21 mg/100 g), Crude fat (10.60 + 0.65 mg/100 g), Ash (5.40 + 0.30 mg/100g), Carbohydrate (74.49 + 0.23 mg/100 g) and Energy (407.80 Kcal). The results of this work showed that concurrent administration of the extract of Gnetum africana affected some of the pharmacokinetic parameters of chloroquine. Malaria patients on chloroquine therapy should therefore be advised to beware of consuming Gnetum africana.
Authors and Affiliations
Olorunfemi Eseyin| Department of Pharmaceutical and Medicinal Chemistry, Faculty of Pharmacy, University of Uyo, P.O. Box 4274, Uyo, Akwa Ibom, Nigeria, Aniekan Ebong| Department of Pharmaceutical and Medicinal Chemistry, Faculty of Pharmacy, University of Uyo, P.O. Box 4274, Uyo, Akwa Ibom, Nigeria, Anefiok Ubobre| Department of Pharmaceutical and Medicinal Chemistry, Faculty of Pharmacy, University of Uyo, P.O. Box 4274, Uyo, Akwa Ibom, Nigeria, Johnson Ekarika| Department of Pharmaceutical and Medicinal Chemistry, Faculty of Pharmacy, University of Uyo, P.O. Box 4274, Uyo, Akwa Ibom, Nigeria, Imo Udo| Department of Biopharmacy and Clinical Pharmacy, Faculty of Pharmacy, University of Uyo, P.O. Box 4274, Uyo, Akwa Ibom, Nigeria
Keywords
Related Articles
- EP ID EP8873
- DOI 10.3889/MJMS.1857-5773.2012.0220
- Views 288
- Downloads 16
Aqueous Extract of Juglans Nigra Prevents Lead Induced Testicular Toxicity in Rats
Background. Lead is a heavy metal that has been known for its adverse effects on many body organs and systems and thus their functions. Aim. In this study, the toxic effect of lead on the testicular system was investig...
Clinico-Pathological Presentation of Colorectal Cancer Seen in Lagos State University Teaching Hospital
Aim: The objective is to describe the age and gender distribution, pattern of presentation, sites of colorectal cancers and the histological types of colorectal cancers seen over a 5 year period in a tertiary health in...
Association between HLA-A, HLA-C and HLA-B Genes and Ankylosing Spondylitis in Macedonian Population
Aim: The aim of this study was to determine the association of HLA-A, -C and -B genes with ankylosing spondylitis in patients from the Republic of Macedonia. Material and Methods: This study included 307 subjects (250...
In Vitro Susceptibility Testing of Aspergillus and Non-Aspergillus Filamentous Moulds to Antifungal Agents: Evaluation of Three Different Methods
Aim: The aim of this study was to evaluate the suitability of Sensititre YeastOne (SYO) method for susceptibility profiles’ determination of non-Aspergillus moulds and of E-test for Aspergillus spp. and non-Aspergill...
Factors Associated With Nonalcoholic Fatty Liver Disease in Obese Adolescents
Background and Objectives: Nonalcoholic fatty liver disease (NAFLD) is a common cause of liver disease in children and adolescents. The aim of this study is to investigate the prevalence of NAFLD in a sample of obese a...