Changes in Some Pharmacokinetics Parameters of Chloroquine by Gnetum Africana
Journal Title: Macedonian Journal of Medical Sciences (MJMS) - Year 2012, Vol 5, Issue 3
Abstract
Effect of Gnetum africana on the pharmacokinetic parameters of chloroquine was investigated. Chloroquine phosphate (200 mg/Kg) was concurrently administered to overnight fasted albino rats. Blood samples were collected 15, 30, 60, 120, 240 and 480 minutes after administration through cardiac puncture. Serum concentration of chloroquine was evaluated spectrophotometrically. The results indicated that the extract significantly decreased Cmax (9.17%), Ka (3.06%), Ke (45.38%), Cl(48.46%) and AUC (0-8) (16.90%). The extract also increased the values of t1/2 (83.11%), tmax (100.00%). The LD50 of the extract was 5.25 g/Kg. Phytochemical screening revealed the presence of steroids, tannins, flavonoids and traces of phlobatanins and alkaloids. Proximate and elemental analyses showed that the plant contained Sodium (26.37 + 0.01ppm), Potassium (32.84 + 0.02 ppm), Copper (0.01 + 0.00 ppm), Calcium (6.53 + 0.01ppm), Magnesium (7.58+ 0.02 ppm), Iron (2.01 + 0.02 ppm), Zinc (0.93 + 0.03 ppm), Lead (0.02 + 0.01 ppm), Moisture (10.90 + 0.91 mg/100 g), Crude protein (15.31 + 1.12 mg/100g), Crude fibre (4.20 + 0.21 mg/100 g), Crude fat (10.60 + 0.65 mg/100 g), Ash (5.40 + 0.30 mg/100g), Carbohydrate (74.49 + 0.23 mg/100 g) and Energy (407.80 Kcal). The results of this work showed that concurrent administration of the extract of Gnetum africana affected some of the pharmacokinetic parameters of chloroquine. Malaria patients on chloroquine therapy should therefore be advised to beware of consuming Gnetum africana.
Authors and Affiliations
Olorunfemi Eseyin| Department of Pharmaceutical and Medicinal Chemistry, Faculty of Pharmacy, University of Uyo, P.O. Box 4274, Uyo, Akwa Ibom, Nigeria, Aniekan Ebong| Department of Pharmaceutical and Medicinal Chemistry, Faculty of Pharmacy, University of Uyo, P.O. Box 4274, Uyo, Akwa Ibom, Nigeria, Anefiok Ubobre| Department of Pharmaceutical and Medicinal Chemistry, Faculty of Pharmacy, University of Uyo, P.O. Box 4274, Uyo, Akwa Ibom, Nigeria, Johnson Ekarika| Department of Pharmaceutical and Medicinal Chemistry, Faculty of Pharmacy, University of Uyo, P.O. Box 4274, Uyo, Akwa Ibom, Nigeria, Imo Udo| Department of Biopharmacy and Clinical Pharmacy, Faculty of Pharmacy, University of Uyo, P.O. Box 4274, Uyo, Akwa Ibom, Nigeria
Keywords
Related Articles
- EP ID EP8873
- DOI 10.3889/MJMS.1857-5773.2012.0220
- Views 331
- Downloads 16
Respiratory and Nasal Symptoms, Immunological Changes, and Lung Function in Industrial Bakers
Background: Several studies reported that occupational exposure in bakery may cause respiratory impairment in exposed workers. Aim: To assess the respiratory effects and immunological changes of occupational exposure i...
Influence of Hyperthermic Environmental Temperature on Adenosine Deaminase Activity in Serum and Lymphoid Organs of Wistar Rats
Aim: To analyze the influence of the hyperthermic environmental temperature (35 ± 1°C) on the adenosine deaminase activity (ADA) in tissues rich with lymphoid cells in Wistar rats. Material and Methods: The activity...
Who is Who - Current Scientific Impact of the Medical Staff Affiliated at the Institutes, Faculty of Medicine, University “Ss Kiril and Metodijâ€, Skopje, Republic of Macedonia
Aim. The aim of this study was to investigate current individual scientific impact of the academic staff employed at the Institutes, Faculty of Medicine, University “Ss Kiril and Metodijâ€, Skopje, Republic of Maced...
Has Ghrelin an Impact on Metabolism and Anthropometric Measurements of Pre- and Full Term Newborns?
Background/aim. Recent literature has questioned ghrelin influence on postnatal metabolism. Studies of the effect of cord plasma ghrelin level on newborn metabolism are few. This study aimed to compare pre- and full te...
Multidiciplinary Treatment of a Haemophilic Person with Total Hip Replacement Surgery- A Case Report
Background: Treatment of hemophilic arthropathy may be conservative and operative. Conservative therapy includes medications and physiotherapy, and surgery includes synovectomy, tendon release, capsulotomy, osteotomy a...