CHANGES IN TESTIS PROTEIN AND METABOLIC ENZYME ACTIVITIES IN RATS INDUCED BY EPICHLOROHYDRIN
Journal Title: International Journal of Pharmacognosy - Year 2015, Vol 2, Issue 6
Abstract
In the present study, an attempt was made to evaluate the changes in testis protein and metabolic enzyme activities induced by epichlorohydrin (ECH), twenty-four albino male rats were divided randomly into four groups of six rats each. One group was left untreated as controls, and the other three groups were administered, respectively, for twelve consecutive weeks, (2) 50 mg of ECH /kg/b.wt, (3) 75 mg of ECH /kg/b.wt and (4) 100 mg of ECH /kg/b.wt. In comparison with the control group, the doses of ECH (75 mg/kg/b.wt and 100 mg/kg/b.wt) resulted in lower protein levels and higher lactate dehydrogenase (LDH) activities in the testis of male rats than in control rats. The activity of gamma-glutamyl transpeptidase (γ-GT) decreased significantly at the doses of ECH (75 mg/kg/b.wt and 100 mg/kg/ b.wt) group than in the ECH (50 mg/kg/b.wt) and control group. However, a significant reduction in the activities of Na+/K+- , Mg2+-and Ca2+-ATPases in the (75 mg/kg/b.wt and 100 mg/kg/b.wt) ECH treated animals than control rats. Therefore, these changes in testis protein and spermatogenesis-dependent enzymes undoubtedly affect the physiological functions of the testis, which may thereby cause low sperm motility.
Authors and Affiliations
M. Marimuthu et al.
Keywords
Related Articles
- EP ID EP556408
- DOI -
- Views 94
- Downloads 0
REVIEW ON RESEARCH STUDIES OF VASAPATRA (LEAF OF ADHATODA VASICA NEES.)
Plants have been used for health and medical purposes for several thousands of years. The clinical experience built over many centuries provides a substantial basis for the safe and effective use of herbal medicines, not...
DETERMINATION OF MEXILETINE IN PHARMACEUTICAL PREPARATIONS BY LINEAR SWEEP VOLTAMMETRY
A simple and rapid method for the determination of mexiletine in pharmaceutical preparations was developed and validated using linear sweep voltammetry (LSV). The proposed method was based on electrochemical oxidation of...
ANTIDIABETIC POTENTIAL OF IVY GOURD (COCCINIA GRANDIS, FAMILY: CUCURBITACEAE) GROWN IN SRI LANKA: A REVIEW
Leaves of ivy gourd; Coccinia grandis (L.) Voigt (Family: Cucurbitaceae) is one of the well-known leafy vegetables, which has been consumed by Sri Lankans for centuries. The therapeutic potential of ivy gourd against dia...
PHYTOCONSTITUTENTS OF MEDICINALLY IMPORTANT PLANT ANDROGRAPHIS PANICULATA NEES
Andrographis paniculata Nees is a plant that has been effectively used in traditional Asian medicines for centuries. It’s perceived “blood purifying” property and also for medicinal properties. The present paper deals to...
ANTI-HYPERGLYCEMIC PLANTS USED BY THE TRADITIONAL HEALER OF WEST GODAVARI DISTRICT, ANDHRA PRADESH, INDIA
A survey was conducted to collect information about the effective medicinal plants used by the Traditional healer to treat diabetes. The use of herbal drugs increased worldwide because of the lack of side effects and eff...