Changes in the expression of molecular markers of peripheral blood lymphocyte activation in patients with small (T1) choroidal melanoma after transpupillary thermotherapy
Journal Title: Офтальмологический журнал - Year 2019, Vol 0, Issue 5
Abstract
Background: Expression of some functional molecules on peripheral blood lymphocytes is critically important for the development of adequate antitumor response. Purpose: To investigate changes in the expression of molecular markers of peripheral blood lymphocyte activation in patients with small (T1) choroidal melanoma (CM; measuring ≤ 3 mm in protrusion into the vitreous and ≤ 12 mm in basal dimension) after transpupillary thermotherapy (TTT) delivered using our methodology. Materials and Methods: We investigated the expression of molecular markers (СD7+, CD25+, CD38+, CD45+, CD54+, CD95+, CD150+) of peripheral blood lymphocyte activation using the routine methodology in 16 patients (12 women (75%) and 4 men (25%); mean age, 55.4 years (11.2 years)) with small (T1) CM at baseline and after a course of TTT delivered using our methodology. Statistical analyses were conducted using Statistica 10 (StatSoft, Tulsa, OK, USA) software. Results: Four-day activity of all examined peripheral blood lymphocyte subpopulations in patients was observed in response to the curative effect of 810-nm diode laser TTT on CM. However, statistically significant increases were found only for the expression of the costimulatory molecule inducing cytokine secretion (CD7+) and proaptotic lymphocyte activity due to an increased share of CD95+-phenotype cells. Conclusion: The expression of molecular markers of peripheral blood lymphocyte activation, especially the expression of the costimulatory molecule inducing cytokine secretion (CD7+) and proaptotic lymphocyte activity due to an increased share of CD95+-phenotype cells, increases within the course of TTT for the small (T1) CM.
Authors and Affiliations
I. Tsukanova, S. Poliakova, L. Velichko, O. Bogdanova
Keywords
Related Articles
- EP ID EP664971
- DOI 10.31288/oftalmolzh201952729
- Views 93
- Downloads 0
Serum VEGF levels in infants at risk for developing retinopathy of prematurity
Background: Because excessive growth of abnormal retinal vessels in the developing eye of the premature infant underlies retinopathy of prematurity (ROP), it may be hypothesized that a change in vascular endothelial grow...
Comparison study of results of vitrectomy and vitrectomy with scleral buckling for the treatment of patients with rhegmatogenous retinal detachment at high risk proliferative vitreoretinopathy
The aim of our study was to analyze the effectiveness of vitrectomy and vitrectomy with scleral buckling in patients with a high risk of proliferative vitreoretinopathy. Material and Methods: Of the 367 patients (394 ey...
Physiological properties of fluid circulation in the crystalline lens in animals with regard to a phase of accommodation
The work was supported by Russian Fund of Fundamental Studies (Project No 16-06-00439). Background. Traditional ideas about the fluid circulation in the lens assume its movement through the lens capsul...
Accidental intralenticular injection of dexametasone intravitreal implant during the treatment of refractory diabetic macular oedema
This article deals with the clinical case of accidental intralenticular injection of dexamethasone implant during the treatment of refractory diabetic macula oedema. The paper is based on a comprehensive research of simi...
Intraoperative changes in intraocular temperature during vitrectomy procedures with irrigating solutions differing in temperature
Background: Intraoperative intraocular media and irrigation fluid temperature monitoring is not performed during vitreoretinal surgery in current clinical practice. Purpose: To investigate intraoperative changes in intr...