Changes of coagulation function and other indicators of the thawed FFP and FLP at 2-6℃
Journal Title: Chinese Journal of Blood Transfusion - Year 2024, Vol 37, Issue 9
Abstract
Objective To observe the changes of coagulation factor activity and protein content of the thawed fresh frozen plasma (FFP) and fresh liquid plasma (FLP) during storage at 2-6℃, and to provide reference for exploring the appropriate storage time of FFP at 2-6℃ after thawing. Methods The small-thaw group and the large-thaw group were respectively detected for the activity of coagulation factor FⅤ (FⅤ∶C) and FⅧ(FⅧ∶C), and the levels of fibrinogen (Fib), total protein (TP) and albumin (Alb) in TTP at 1, 2, 3, 4, 5, 6 and 7 days after thawing. And the FLP was detected for FⅤ∶C, FⅧ∶C, Fib, TP and Alb at 1, 2, 3, 4, 5, 6, 7 days and 1, 6, 11, 16, 21, 26 and 31 days after preparation, respectively. Results In FFP group, FⅧ∶C decreased gradually with the prolongation of storage time after melting (P<0.05), and decreased by 37.4% and 47.6% respectively in the two groups on the 7th day. There was no statistical difference in FⅤ∶C, Fib, TP and Alb (P>0.05). In FLP group, FⅧ∶C decreased gradually with the prolongation of storage time after melting (P<0.05). There was no statistical difference in FⅤ∶C in 7-day storage group (P>0.05), but it decreased gradually in 31-day storage group (P<0.05). There was no statistical difference in Fib, TP and Alb (P>0.05). Conclusion Although FⅧ∶C is decreased in thawed FFP stored at 2-6℃ for 7 days, it is still about 52.4%, which should be able to play a normal role in clinical practice.
Authors and Affiliations
Jie PAN, Xiangyun YAN, Zhiyong LU, Danhong WANG, Qianqian CHEN, Hongjie CHEN, Yuting RUAN
Keywords
Related Articles
- EP ID EP748053
- DOI 10.13303/j.cjbt.issn.1004549x.2024.09.014
- Views 54
- Downloads 0
Chimeric antigen receptor T-associated cytokines release syndrome managed by therapeutic plasma exchange and tumor necrosis factor inhibitors: a case report
Objective To learn more about the role of therapeutic plasma exchange in the management of cytokines release syndrome(CRS) after chimeric antigen receptor T(CAR-T) infusion by reviewing and analyzing the diagnosis and tr...
An improved method to generate megakaryocytes from human induced pluripotent stem cells
Objective To optimize the existing spin-EB method and promote human induced pluripotent stem cells (hiPSCs) differentiate into megakaryocytes (MKs). Methods In this study, the initial inoculation amount of hiPSCs was inc...
Analysis on phenotype and genotyping of CisAB subtypes: 12 Cases
Objective To analyze and master the serological and genetic characteristics of the samples with CisAB subtype and their genetic background. Methods From January 2018 to January 2022, blood samples with discrepant ABO blo...
Analysis of red blood cell alloimmunization among inpatients: 104 588 cases
Objective To analyze the yield, specificity and detection time of red blood cell(RBC)alloimmunization in 104 588 inpatients. Methods The clinical information of patients who underwent at least one antibody screening in o...
Blood transfusion adverse event management system: construction and application
Objective To establish a blood transfusion adverse event management system and apply it to adverse events management, so as to enhance the ability to identify and process reports as well as prevent adverse events. Method...