Changes of indices of diurnal blood pressure monitoring under the influence of treatment in patients with essential hypertension complicated with hemorrhagic stroke after early recovery period
Journal Title: Серце і судини - Year 2019, Vol 0, Issue 2
Abstract
The aim — to compare the indices of diurnal blood pressure monitoring (DBPM) in patients with essential hypertension (EH) іn ≥ 6 months after hemorrhagic stroke (HS) before and after treatment with combination of amlodipine, valsartan, hydroclorothiazide (if necessary) and magnesium oxide monohydrate. Materials and methods. The main group included 33 patients, the comparison group comprised 13 persons. In the first group the office blood pressure (BP) was і 140/90 mm Hg, in the second one it was lower. The groups were matched by main indicators. DBPM was performed twice (before and after treatment) for the main group of patients, and once for the comparison group patients. Results and discussion. In the main group, before and after treatment the mean systolic blood pressure (SBP) was 110.1 ± 16.0 mm Hg and 102.3 ± 12.6 mm Hg, respectively, at daytime, 102.6 ± 17.3 and 83.9 ± 8.1 mm Hg at night, 109.7 ± 15.7 and 96.3 ± 11.9 mm Hg (p < 0.05) per day. The maximum SBP at daytime in the main group was higher before the treatment (169.3 ± 18.4 mm Hg, p < 0.05). The value of the standard deviation of SBP and pulse BP decreased after treatment (p < 0.05). The value of the mean real variability of SBP in the main group was 11.27 ± 2.73 mm Hg before treatment and 9.74 ± 1.84 mm Hg (p < 0.05) after it. Diurnal index of SBD in the main group was 4.95 ± 9.67 % before treatment and 11.44 ± 5.43 % after it. Conclusions. The treatment of patients with EH, who had suffered HS ≥ 6 months before and had office BP ≥ 140/90 mm Hg, with combination of amlodipine (daily dose 5 — 10 mg), valsartan (daily dose 80 — 160 mg), hydroclorothiazide (12.5 mg if necessary) on the basis of chronotherapy approach and magnesium oxide monohydrate (456 mg daily during 1 month period) permits achieving the control of BP according to DBPM data in 73 % of patients. This treatment also permits statistically significant decreasing of short‑term BP variability, in particular, the standard deviation in all time intervals and the average real variability of SBD.
Authors and Affiliations
O. V. Tkachyshyn
Keywords
Related Articles
- EP ID EP608152
- DOI 10.30978/HV2019-2-40
- Views 102
- Downloads 0
Assessment of life quality of patients with trophic ulcer of venous genesis
The aim — to assess life quality of patients with trophic ulcers of venous genesis Materials and methods. A survey of 85 patients who are on inpatient treatment for venous trophic ulcers was conducted. According to the C...
Markers of bone remodeling, 25(ОH)D3 level and lipid metabolism parameters in elderly women with uncomplicated arterial hypertension
The aim of the work is to make a comparative analysis of the parameters of bone remodeling, lipid and calciumphosphor exchange and 25(ОH)D3 level in elderly women with uncomplicated arterial hypertension (AH) and withou...
Prognostic significance of soluble ST2 as predictor of late left ventricular remodeling after ST-segment elevation myocardial infarction
The aim — to study the prognostic value of soluble ST2 regarding the development of pathological left ventricular remodeling (LVR) 6 months after acute ST‑ segment elevation myocardial infarction (STEMI) Materials and m...
Assessment of frequency of cranial nerve lesions after carotid artery surgery
The aim — to improve the methods of treatment of carotid pathology by analyzing the frequency of the cranial nerves’ lesions through generalization of the literary sources and the results of own observations. Materials...
Thrombosis of perforating veins: frequence, structure, features of treatment and connection with cancer
Acute varicose vein thrombosis is one of the main varicose disease complications. It causes deep vein thrombosis in 10 — 25 % and pulmonary embolism — in 10 % of patients. The aim — to study the frequency, nature, distr...