Changes of inflammatory factors, reactive oxygen species and cognitive function in mice after brain-blast injury
Journal Title: Journal of Acute Disease - Year 2018, Vol 7, Issue 6
Abstract
Objective: To study the changes of cognitive function in mouse after brain-blast injury. Methods: Fourty healthy male C57BL/6 mice were randomly divided into model group and control group. After 24 h of injury, histopathological changesc and reactive oxygen species changes were observed under microscope; while changes of inflammatory cytokines content were determined by Western-blot. Four weeks later, Morris water maze method was used to detect the cognition impairment. Results: HE staining showed blast induced brain injury in C57BL/6 mice. Compared with normal control group, the expression of IL-1毬,IL-4, IL-6 were significantly increased in brain tissue of model group whereas IL-10 was significantly decreased (P<0.05); ROS expression in the hippocampus of model group mice was significantly increased compared with that in the control group. Morris water maze showed cognition impairment in mice after brain-blast injury. Conclusions: Brain-blast injury causes cognition impairment in mice, which may be related to the occur of inflammatory change and oxidative stress in the early stage.
Authors and Affiliations
Ying Liu, Yun-En Liu, Chang-Ci Tong, Hong-Xu Jin
Keywords
Related Articles
- EP ID EP462118
- DOI 10.4103/2221-6189.248025
- Views 122
- Downloads 0
Analysis of American skills and its educational inspiration for Chinese medicine
There are various modes of American pre-hospital emergency with different rescue levels which can meet the needs of out-of-hospital rescue in different environments and grades. Pre-hospital emergency workers are relative...
Survival following an impalement injury through the perineum in association with high voltage electrical burns: A case report
We reported a case of a 30-year-old man who reportedly sustained electrical burns and fell from a high voltage electric pole about 50 meter high onto a metal that caused impalement injury. In addition, he sustained full-...
Acute proptosis: Unusual initial presentation of sinonasal inverted papilloma
Inverted papilloma is an uncommon histopathological finding of maxillary sinus tumor. We reported here a rare case of inverted papilloma of maxillary sinus presented initially with ipsilateral proptosis. A middle-aged la...
Necrotizing fasciitis following mild trauma in a patient with mellitus diabetes: a case report
Rationale: Necrotizing fasciitis is a rare infection of fascia tissues. It progresses quickly and has high morbidity and mortality. In this study, we aimed to explore a case of necrotizing fasciitis in a diabetic patient...
Tardive phenomenon presenting as isolated dysarthria: A rare entity mimicking stroke
Distinguishing stroke mimics constitutes a considerable challenge for clinicians in emergency department. Here, we illustrate an extremely rare patient presenting with acute onset isolated dysarthria, who finally receive...