Changes of Serum Transaminases in Chronic Alcoholics Undergoing Deaddiction Treatment
Journal Title: Journal of Medical Science And clinical Research - Year 2015, Vol 3, Issue 3
Abstract
Alcoholism is a major health issue with socioeconomic consequences. Clinicians can use cost effective and easily available biochemical measurements to objectively assess patients’ current or past alcohol use. Commonly known as the liver enzymes, the serum aminotransferases include: aspartate aminotransferase (AST), alanine aminotransferase (ALT) which reflect liver injury due to excessive alcohol consumption. The aim of this case control study was to estimate the transaminases (AST and ALT) and compare their levels in chronic alcoholics undergoing deaddiction treatment with apparently healthy age matched controls. 30 cases between 25-60 years of age, selected for the study in the inpatient unit of Dept.of de-addiction centre at Kamineni Institute of Medical Sciences, Narketpally. AST and ALT estimated by modified IFCC UV-Kinetic method by life chem Kit. ALT, and AST in the serum were significantly higher in alcoholics before de-addiction which decreased significantly after one month and two months of alcohol withdrawal regimen. But the values did not reach normal control levels .Thus these changes of serum transaminases observed in chronic alcoholics offer use not only as diagnostic markers but also as prognostic markers and are helpful in management of chronic alcoholics.
Authors and Affiliations
Archana. A. Dharwadkar
Keywords
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