Changing clinical and microbiological profile of Candidiasis in VLBW babies in NICU of a tertiary care Hospital
Journal Title: INTERNATIONAL JOURNAL OF CURRENT RESEARCH IN MEDICAL SCIENCES - Year 2018, Vol 4, Issue 2
Abstract
Introduction: Candida infection is a severe complication during the neonatal period among VLBW. The aim of this prospective observational study was to find the incidence, clinical and microbiological profile of candidiasis in VLBWs admitted in NICU. Material and methods: This study was conducted in NICU, Department of Pediatrics, Government Medical College Amritsar (Punjab) India over one year and included all VLBW babies admitted in NICU. The baseline variables, treatment and interventions done were recorded. In babies having clinical deterioration after one week of stay blood and urine specimens were sent to microbiology lab for Candida species identification and sensitivity pattern. The incidence per 1000 patient and per 1000 device days was calculated. Results : Out of 131 VLBW neonates, 91 completed the study. Incidence of Candida sepsis was 8.04/1000 patient day. We found oral thrush, poor perfusion, hypotension, abdominal distension, tachycardia and temperature instability as clinical manifestations of Candidiasis. Non albicans Candida species (61%) were predominant out of which 48% were Candida tropicalis followed by Candida albicans (39%). Most of the Candida species were sensitive to Amphotericin B (95%), Itraconazole (95%) and Voriconazole (95%) followed by Nystatin (82%), Fluconazole (74%). Mortality related to Candida infection was 23%. Conclusion : In our study non albicans were more prevalent and fluconazole has shown increasing resistance for Candidiasis.
Authors and Affiliations
Dr Ashwani Kumar,Dr Ranjit Singh,Dr Karnail Singh,Dr Kanwardeep Singh, Dr MS Pannu,Dr Palwinder Singh,Dr NS Neki,
Keywords
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- EP ID EP552749
- DOI 10.22192/ijcrms.2018.04.02.008
- Views 139
- Downloads 0
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