Changing Treatment May Affect the Predictive Ability of European Treatment Outcome Study Scoring for the Prognosis of Patients with Chronic Myeloid Leukemia
Journal Title: Turkish Journal of Hematology - Year 2017, Vol 34, Issue 1
Abstract
Objective: Previous studies compared the predictive ability of the European Treatment Outcome Study (EUTOS), Sokal, and Hasford scoring systems and demonstrated inconsistent findings with unknown reasons. This study was conducted to determine a useful scoring system to predict the prognosis of patients with chronic myeloid leukemia (CML) and identify the probable factors that affect the scoring. Materials and Methods: This is a retrospective cohort study. The predictive ability of EUTOS and the factors that affect scoring were analyzed in 234 Chinese chronic-phase CML patients treated with frontline imatinib, including a few patients temporarily administered hydroxyurea for cytoreduction before imatinib. Patients were stratified into different risk groups according to each scoring system to assess the treatment outcomes and the predictive ability of EUTOS scores between patients who received imatinib during the entire followup period and patients who received altered treatment because of intolerance, progression, and treatment failure. Results: Sixty-one (26.0%) patients received altered treatments during the follow-up. In the EUTOS low- and high-risk groups, the 5-year overall survival was 94.6% and 84.7% (p=0.011), 5-year eventfree survival was 92.6% and 77.6% (p=0.001), and 5-year progressionfree survival (PFS) was 95.3% and 82.4% (p=0.001), respectively. The predictive ability of EUTOS was better than that of the Sokal and Hasford scores (p=0.256, p=0.062, p=0.073) without statistical significance. All three scoring systems were valid in predicting early optimal response. Kaplan-Meier analysis showed a high association between overall PFS and the EUTOS scores in the standard-dose imatinib group (p<0.001). Conclusion: This study suggests that the EUTOS scoring system could predict the outcome of chronic-phase CML patients treated with standard-dose imatinib. Altered treatment is a crucial factor that affects the prognostic impact of EUTOS scoring. Achieving complete cytogenetic response at 18 months is an essential factor in predicting the prognosis of patients with CML.
Authors and Affiliations
Jing Huang, Leyan Wang, Lu Chen, He Qun, Xu Yajing, Chen Fangping, Zhao Xielan
Keywords
Related Articles
- EP ID EP223908
- DOI 10.4274/tjh.2016.0156
- Views 79
- Downloads 0
The Relationship Between Seasonal Variation in the Diagnosis of Acute Lymphoblastic Leukemia and its Prognosis in Children
To the Editor, Although many studies have examined the prognostic factors of childhood ALL, a limited number have investigated the correlation between the season and/or month in which ALL is diagnosed and its prog...
Metastatik Meme Kanserinin Soğuk Tipte Otoimmun Hemolitik Anemi Olarak Sıradışı Başvurusu
β-Talasemi Taşıyıcıda HbA2 Düzeyi Düşüklüğü
Effectiveness of Ankaferd BloodStopper in Prophylaxis and Treatment of Oral Mucositis in Childhood Cancers Evaluated with Plasma Citrulline Levels
.
Aynı Mezenterik Lenf Bezinde B-Hücreli Kronik Lenfositik Lösemi ve Kolon Adenokanserinin Eş Zamanlı Saptanması