CHANGING TREND OF ANTIBIOTIC SUSCEPTIBILITY PATTERN OF COMMON GRAM NEGATIVE BACILLI ISOLATED FROM MEDICAL INTENSIVE CARE UNIT OF TERTIARY CARE HOSPITAL AHMEDABAD, GUJARAT, INDIA
Journal Title: Journal of Drug Discovery and Therapeutics - Year 2013, Vol 1, Issue 4
Abstract
Introduction: Resistance among Gram-negative bacilli antimicrobial remains a significant problem for patients in the intensive care unit (ICU). Multi-resistant gram-negative bacilli are important pathogens in ICUs, causing high rate of mortality. The purpose of this study was to investigate change in antimicrobial resistance patterns among common Gram-negative bacilli isolated from Medical ICU patients.Method and Materials: In duration of two years (2011, 2012) all Gram negative bacilli isolated from different clinical specimens from MICU were evaluated for sensitivity patterns by Kirby-Bauer disc diffusion method.Results: The most frequently isolated organisms were Acinetobacter baumannii, Pseudomonas aeruginosa, Escherichia coli and Klebsiella sp.. Antibiotic susceptibility patterns significantly declined in those organisms, A baumannii showed decreased susceptibility to carbapenem (4.2% to 56.2% resistant), ampicillin sulbactam (48.1 to 62.5% resistant)and netilmycin (68.5 to 87.7% resistant).Pseudomonas aeruginosa also showed decreased susceptibility for carbapenem (6.2 % to 43.9% resistant),netilmycin and for quinolones(II)(resistant up to 65.1 & 76.2% respectively).Same way susceptibility to commonly use antibiotics for E.coli and Klebsiella sp. were also decreased.Conclusion: Antimicrobial resistance is an emerging problem in MICU. Continuous monitoring of antimicrobial susceptibility and strict adherence to infection prevention guidelines are essential to eliminate major outbreaks in the future.
Authors and Affiliations
Dr. Parimal H. Patel*| Tutor, Department of Microbiology, Smt. NHL Municipal Medical College Ahmedabad, India-380006, Dr. Sanjay Rathod| Associate Professor, Department of Microbiology, Smt. NHL Municipal Medical College Ahmedabad, India-380006, Dr. Bimal Chauhan| Assistant Professor, Department of Microbiology, Smt. NHL Municipal Medical College Ahmedabad, India-380006, Dr. Hetal Rathod| 1st Year Resident, Department of Microbiology, Smt. NHL Municipal Medical College Ahmedabad, India-380006, Dr. Jayshree Pethani| Associate Professor, Department of Microbiology, Smt. NHL Municipal Medical College Ahmedabad, India-380006, Dr. Parul Shah| Professor & Head, Department of Microbiology, Smt. NHL Municipal Medical College Ahmedabad, India-380006
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