Changing Trends in Antibiotic Resistance Profile of Salmonella enteritica species in a Tertiary Care Hospital in Central Kerala
Journal Title: Journal of Medical Science And clinical Research - Year 2017, Vol 5, Issue 10
Abstract
Background: Infections due to salmonella is an important cause of significant morbidity and mortality in many developing countries. Salmonella Typhi being the major causative agent and affects roughly 21.6 million people each year. Objective: A retrospective study was conducted to analyze the antibiotic sensitivity pattern of Salmonella enterica species isolated from clinical specimen from a tertiary care hospital. Materials and Methods: A total of 39 Salmonella enterica species isolated from the blood and stool samples were analyzed from the period of 2011 January to 2017 June. Patients were in the age group of 2-63 years. Salmonella Typhi was the predominant isolate 74% (29). These isolates were tested for antimicrobial susceptibility according to the CLSI guidelines. Results: No Multidrug resistant (MDR) strains were isolated where as sensitivity to Ciprofloxacin and Azithromycin decreased gradually since 2012. Conclusion: Since 1987, when ciprofloxacin was approved for clinical use, fluoroquinolones (FQs) have been widely prescribed for a diverse range of infections, including bacterial enteritis and typhoid fever. A broad antibacterial spectrum, favorable safety profile, and excellent oral absorption have contributed to the popularity of these agents. However, marked increases in FQ resistance were observed within a decade of the introduction of these agents, and Salmonella infections have typified this trend. A careful consideration should be given before deciding the antibiotic for treatment in order to prevent the emergence of antibiotic resistance.
Authors and Affiliations
Dr Reena John
Keywords
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