Changing trends in the Antibiotic susceptibility pattern of Acinetobacter species isolated from clinical specimens over a period of five years from a tertiary care hospital
Journal Title: Journal of Medical Science And clinical Research - Year 2017, Vol 5, Issue 6
Abstract
`Introduction: Acinetobacter spp has emerged as an important nosocomial pathogen worldwide. Antimicrobial resistance pattern of Acinetobacter vary according to species, country of isolation, region & period of time. But the overall trend is one of increasing resistance. Hence effective therapy must be individualised to reflect the periodic differences in regional, local & specific hospital resistance patterns, which makes constant monitoring of antibiogram of Acinetobacter spp essential. Objectives: 1)To study the prevalence of Acinetobacter spp among various clinical samples over a period of 5 years 2)To assess the prevalence of multidrug resistance among the Acinetobacter isolates 3)To study the changing trends in the susceptibility pattern of Acinetobacter isolates over a period of 5 years Methodology: Retrospective analysis of the antibiogram of the Acinetobacter spp was done, which were isolated from various clinical specimens received in the Department of Microbiology in a tertiary care centre during a 5 year period from 2012 to 2016 Results: During the study period, a total of 46005 samples were received for culture, from which 583 (1.3%) Acinetobacter spp were isolated. The prevalence of MDR strains among Acinetobacter increased from 59% in 2012 to 76% in 2016. Analysis of the antibiogram of the Acinetobacter isolates showed a progressive decrease in the susceptibility to third generation Cephalosporins & Piperacillin. The most susceptible agents were Meropenem, Tobramycin & Cefoperazone-sulbactam. Conclusion: MDR Acinetobacter infections in our institution have increased considerably over the past five years. The trends in the antibiotic susceptibility patterns needs to be constantly monitored as it will help to determine the emergence of drug resistance, to formulate antibiotic policies for empirical therapy and to curb the irrational usage of antimicrobials
Authors and Affiliations
Joana Mary Magdaline
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