CHARACTERISATION AND DISSOLUTION PROPERTIES OF KETOPROFEN IN BINARY SOLID DISPERSION WITH CHITOSAN
Journal Title: Progress on Chemistry and Application of Chitin and its Derivatives - Year 2014, Vol 0, Issue
Abstract
BCS class II includes drugs with low solubility and high permeability. Ketoprofen is an example of this class of drugs. The aim of the study was to investigate the effect of chitosan with average molecular weights in various formulations on the dissolution of ketoprofen incorporated into this polymer carrier. The study investigated ketoprofen in solid dispersions using a method of the solvent evaporations at the drug to polymer ratios of 1:9. 3:7, and 5:5. The highest dissolution of fenofibrate, amounting to 98.8%, was observed after 60 minutes from solid dispersions with a drug-polymer weight ratio 1:9 in the presence of chitosan B and was 32-times higher in relation to the amount of added polymer in comparison to the solubility of pure drug. DSC and IR investigations showed that ketoprofen remained in its crystalline state in solid dispersion. There was no change in the chemical structure of the drug after the incorporation of the drug onto the polymer. Chitosan has been proposed as a useful excipient for enhancing the bioavailability of poorly water-soluble compounds.
Authors and Affiliations
Bożena Grimling, Agata Górniak, Jan Meler, Maria Szcześniak, Janusz Pluta
Keywords
Related Articles
- EP ID EP73398
- DOI 10.15259/PCACD.19.03
- Views 116
- Downloads 0
VISCOMETRIC STUDIES OF MICROCRYSTALLINE CHITOSAN/POLY(VINYL ALCOHOL) MIXTURES
In the present paper, the results of viscosity measurements in dilute solutions of microcrystalline chitosan (MCCh) with poly(vinyl alcohol) (PVA) of different degrees of hydrolysis are presented. Microcrystalline chitos...
SURFACE PROPERTIES OF CHITOSAN COMPOSITES WITH POLY(VINYL ALCOHOL) AND HYDROXYAPATITE
Surface properties of composites containing chitosan (Ch), poly(vinyl alcohol) (PVA) with hydroxyapatite (HAP) were investigated by contact angle measurements and atomic force microscopy (AFM). Thin films of Ch/HAP and C...
FORMATION OF FIBRES AND SPHERES FROM CHITIN SOLUTION
The applications of chitin are limited due to its insolubility in most organic solvents. The chemical modification of chitin to generate new bio-functional materials can bring more desirable properties. A concentration o...
THE USE OF POLYSACCHARIDES FOR ACID RED 18 ANIONIC DYE REMOVAL FROM AQUEOUS SOLUTIONS
In the paper, the adsorption of Acid Red 18 (AR18) on chitosan (CHs), sodium carboxymethyl cellulose (CMC) and agar (AGA) was researched. The adsorption capability of biosorbents was examined as a function of initial pH,...
ADSORPTION OF BASIC YELLOW 28 (BY 28) AND ACID YELLOW 23 (AY 23) DYES ONTO CHITIN
The present study investigated the sorption of Basic Yellow 28 (BY 28) and Acid Yellow 23 (AY 23) by chitin flakes. The study determined the influence of pH value on adsorption effectiveness and the adsorption capacity o...