Characteristic of <i>ZMYND10</i> Gene’s Promoter Hypermethylation in Nasopharyngeal Carcinoma Biopsies from Vietnamese Patients
Journal Title: Asian Journal of Pharmaceutical Research and Health Care - Year 2018, Vol 10, Issue 3
Abstract
Silencing of tumor suppressor gene, which caused by the DNA hypermethylation, an epigenetic modification, has been reported to be involved in human various cancers, including nasopharyngeal carcinoma. The aims of this study were to identify and evaluate the hypermethylation frequency of the <em>ZMYND10</em> promoter, which located at 3p21.3, in nasopharyngeal biopsies from Vietnamese patients by Nested Methylation Specific PCR (Nested MSP). In current study, ninety tumor biopsies and ninety healthy samples, which were obtained from Cho Ray hospital, were enrolled into study. As the results, the hypermethylation frequency of <em>ZMYND10</em> gene promoter was more frequent in tumor biopsies. In detail, the hypermethylation frequency of <em>ZMYND10</em> gene promoter were 81.11% (73 of 90 samples), and 45.56% (41 of 90 samples) for in NPC biopsies and non-cancerous specimens. A trend toward positive association was found between hypermethylation of <em>ZMYND10</em> gene and nasopharyngeal carcinoma (p < 0.0007). Additionally, the high Odds ratio (OR) and Relative risk were observed (OR = 5.13, RR = 2.49) (p < 0.0001). In conclusion, our data suggested that the hypermethylation of ZMYND10 gene promoter is a significant in nasopharyngeal carcinoma in Vietnamese patients.
Authors and Affiliations
Thuan Duc Lao, Thuy Ai Huyen Le
Keywords
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- EP ID EP474773
- DOI 10.18311/ajprhc/2018/21671
- Views 57
- Downloads 0
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