Characteristics of specific immunological indicators in patients with postoperative relapse of Graves’ disease
Journal Title: Міжнародний ендокринологічний журнал - Year 2018, Vol 14, Issue 1
Abstract
Background. Activity of autoimmune processes had a leading role in the development of relapse of hyperthyroidism. Level of thyroid-stimulating hormone (TSH) receptor antibodies is a basic factor that predetermines the relapse and can be used as a criterion to evaluate its development. A research aim was to study the structural and functional state of the thyroid gland, levels of thyroid peroxidase antibodies and TSH receptor antibodies in patients with postoperative relapse of Graves’ disease during antithyroid therapy. Materials and methods. The group of patients consisted of 25 women aged 23 to 73 years (an average of 53.56 ± 2.31 years). The period from the first surgical treatment to the development of relapse of thyrotoxicosis ranged from 1 to 29 years and averaged 13.33 ± 1.66 years. Results. It was found that the levels of TSH receptor antibodies, which are the main factors in the pathogenesis of Graves’ disease, are not decreased on the background of drug treatment that indicates a lack of perspective of conservative therapy for the post-operative relapse of this disease. Conclusions. When the state of medication compensation for thyrotoxicosis is achieved, it is recommended to conduct the therapy with I131 or surgical treatment of the relapse of Graves’ disease.
Authors and Affiliations
Yu. V. Buldigina, S. L. Shlyakhtich, G. M. Terekhova
Keywords
Related Articles
- EP ID EP275717
- DOI 10.22141/2224-0721.14.1.2018.127095
- Views 45
- Downloads 0
Role of Obesity in the Progression of Diabetic Nephropathy in Patients with Diabetes Mellitus (Literature Review)
The prevalence of obesity has risen proportionally to epidemic and continues to be a major health problem worldwide. The high prevalence of obesity is closely associated with the increased incidence of chronic diseases,...
Analysis of the prevalence and morbidity of thyroid pathology among the population of Kyiv region and Ukraine for 2007–2017
Background. In Ukraine, there is a clear increase in the number of patients with different thyroid pathology. Indicators of the prevalence and morbidity vary in different regions of the country depending on the influence...
Assessment of Glycemia Impact on the Parameters of Sleep in Type 1 Diabetes Mellitus: the Results of Cross-Sectional Cohort Trial
This study demonstrates the impact of glycemia according to daily monitoring of blood glucose on parameters of nocturnal sleep in type 1 diabetic patients, regardless of the glycated haemoglobin level.
Functional State of Pituitary-Gonadal System in Men with Non-functional Pituitary Adenomas and Growth Hormone Deficiency in Adults
We examined 71 adult patients with growth hormone deficiency caused by non-functional masses of chiasmosellar area. Patients were divided into two groups: the first one — men aged 18 to 49 years and the second one — 49 y...
Integrated Treatment of Diabetic Polyneuropathy
No abstract