Characterization and Evaluation of the Suspending Potentials of Corchorus olitorius Mucilage in Pharmaceutical Suspensions
Journal Title: Tropical Journal of Natural Product Research - Year 2017, Vol 1, Issue 1
Abstract
The study was aimed at extraction, characterization and evaluation of suspending potentials of Corchorus olitorius mucilage (COM) in comparison with acacia BP (ACG) in pharmaceutical suspensions. Corchorus olitorius mucilage was extracted from its dried leaves decoction by differential precipitation with acetone, dried and micronized into powder. The powdered mucilage was screened and subjected to physico-chemical and flow properties analyses with acacia BP powder using standard methods. Functional groups elucidation and thermal analysis of the test mucilage was done using Fourier transform infrared spectroscopy (FTIR) and differential scanning calorimetry (DSC) respectively. Paracetamol suspensions were formulated using various concentrations of COM and ACG (1.0 - 3.0 %w/v) and assessed for their sedimentation volume, redispersibility, degree of flocculation, flow rate, particle size, pH, viscosity, drug content and invitro release profile. Drug-excipients compatibility was also assessed. The phytochemical tests revealed the presence of mucilage and carbohydrates and absence of starch and enzymes in the dried mucilage. COM powders had lower pH, percentage moisture content and bulk and tapped densities than ACG powders. The true density, porosity, angle of repose, Carr’s index, Hausner’s ratio and microbial load of COM powders were higher than those of ACG. Formulation containing 1.5 %w/v COM had a comparable suspending property to formulation containing 2.5 %w/v ACG. Results of accelerated stability studies showed no significant change in pH, viscosity, sedimentation volume and degree of flocculation of formulated suspensions. Corchorus olitorius mucilage at the low concentration of 1.5 %w/v could be employed as a suspending agent for formulation of pharmaceutical suspensions.
Authors and Affiliations
Chukwuemeka Paul Azubuike
Keywords
Related Articles
- EP ID EP349532
- DOI 10.26538/tjnpr/v1i1.7
- Views 72
- Downloads 0
Ameliorative effect of coconut oil (Cocos nucifera) on the testes of Norwegian rats intoxicated with untreated crude refinery effluents
Received 07 March 2018 Revised 25 March 2018 Accepted 31 March 2018 Published online 07 April 2018 The study was aimed at determining the effects of untreated refinery effluent on the spermatogenic status of the testes...
Protective Effect of Ethanol Extract of Senna occidentalis Leaf Against Cadmium Induced Hepatotoxicity in Rats
Cadmium is a known environmental and industrial toxicant exposure to which leads to the generation of reactive oxygen species (ROS), with attendant oxidative damage to membrane lipids, cellular proteins and DNA. Recently...
Brine Shrimps Toxicity, Bactericidal and Antifungal activity of Monodora myristica (Gaertn) Essential Oils
Received 31 July 2017 Revised 24 December 2017 Accepted 02 January 2018 Published online 07 January 2018 Essential oils from the seeds and stem bark of Monodora myristica were obtained through hydro-distillation using...
Effect of Short-Term Concomitant Use of Polyherbal Mixture on the Bioavailability of HIV Protease Inhibitors and Organ Damage in Rats
Many herbal remedies are used as complementary therapy to combination antiretroviral therapy (cART). Contrary to the general assumptions that herbal remedies are harmless because of the natural source, many have been fou...
Impact of Yoyo bitters® on the Pharmacokinetic Profile of Ciprofloxacin in Healthy Nigerian Volunteers
Received 17 September 2018 Revised 09 October 2018 Accepted 12 October 2018 Published online 23 October 2018 Ciprofloxacin and Yoyo bitters® (a liquid herbal oral preparation) are readily and widely available as prescri...