Characterization, Antifungal Susceptibility and Phenotypic Virulence Markers of Candida Isolates from Blood Stream Infection
Journal Title: Journal of Clinical Immunology & Microbiology - Year 2021, Vol 2, Issue 3
Abstract
Background: Candidemia is a blood stream infection which is caused by various Candida species in children and adults. About more than 200 species of Candida are identified and only about 10% of Candida species cause human infections. In the Blood Stream Infection (BSI), Candida is the 4th most common isolated organism in the hospitalized and critically ill patients. Identification of Candida species in blood stream infection and antifungal susceptible pattern is urgent need for diagnosis of Candidemia. Objective: To study the spectrum of Candida species in blood stream infection and to study the antifungal susceptibility pattern and virulence factors. Material and Method: A total of 1500 blood culture samples were collected in one year (2019- 2020) at King George Medical University, Lucknow. Out of 1500 patients, 100 blood cultures were positive for Candidemia. Identification of Candida species was done by conventional technique and reconfirmed by MALDI-TOF. Antifungal susceptibility pattern was performed for accuracy of drug concentration which helps clinicians for treatment of patients. Results: We found that the Candida tropicalis 26% were more prevalent than Candida albicans (17%). The most common risk factor for development of Candidemia was ICU admission (55). Resistance of fluconazole for Candida albicans 3(17.65%) and Candida tropicalis 3(11.5%), Candida utilis 1(6.7%), Candida parapsilosis 6(50%), Candida auris 11(100%), Candida glabrata 3(60%), Candida duobushaemulonii 1(100%). Conclusion: As there is a shift to non-albicans candida causing candidemia as well as increase resistance to fluconazole drug which causes high rate of morbidity and mortality in critically ill Candidemia patients. There is need for identification of Candida species and accurate drug for treatment of patients.
Authors and Affiliations
Anshuman Raj, Gopa Banerjee*, Vimala Venkatesh, Prashant Gupta, Shivangi Tripathi, Shailendra Prasad Verma, Nishant Verma
Keywords
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- EP ID EP699108
- DOI http://dx.doi.org/10.46889/JCIM.2021.2304
- Views 65
- Downloads 0
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