Characterization of acute adverse-effect profiles of selected antiepileptic drugs in the grip-strength test in mice.
Journal Title: Pharmacological Reports - Year 2009, Vol 61, Issue 4
Abstract
The aim of this study was to assess the acute adverse effects (neurotoxic) of several antiepileptic drugs (clonazepam, lamotrigine, oxcarbazepine, phenytoin, phenobarbital and topiramate) by measuring skeletal muscular strength in mice using the grip-strength test. Linear regression analysis of grip-strength in relation to drug dose-response allowed us to determine D(50) values, the dosages of antiepileptic drugs that reduced grip-strength in mice by 50% compared to control animals. Each of the antiepileptic drugs studied reduced skeletal muscular strength in mice in a dose-dependent manner. The D(50) for clonazepam was 31.7 mg/kg, lamotrigine - 47.7 mg/kg, oxcarbazepine - 87.3 mg/kg, phenobarbital - 128.7 mg/kg, phenytoin - 69.7 mg/kg, and topiramate - 509.5 mg/kg. In conclusion, the grip-strength test can aid in evaluating acute adverse effects of drugs with respect to their influence on muscular strength in experimental animals.
Authors and Affiliations
Anna Zadrozniak, Ewa Wojda, Aleksandra Wlaź, Jarogniew Luszczki
Keywords
Related Articles
- EP ID EP144659
- DOI -
- Views 83
- Downloads 0
Human micro- and macrovessel-derived endothelial cells: a comparative study on the effects of adrenaline and a selective adenosine A(2)-type receptor agonist under normoxic and hypoxic conditions.
Adrenaline is a highly effective stimulator of cyclic AMP (cAMP) production in microvascular endothelial cells (ECs) - HMEC-1, showing only a moderate activity in macrovascular ECs - HUVEC. In both EC preparations, adren...
Caffeine as a marker substrate for testing cytochrome P450 activity in human and rat.
The current knowledge on the involvement of cytochrome P450 (P450, CYP) isoforms in the metabolism of caffeine in rat and human liver is reviewed. Attention is also paid to species- and concentration-dependent metabolism...
Influence of chronic stress on brain corticosteroid receptors and HPA axis activity.
Background: Disruption of the glucocorticoid negative feedback system evoked in animals by chronic stress can be induced by downregulation of glucocorticoid receptors (GRs) in several brain regions. In the present study,...
Involvement of adenosine receptors in dizocilpine-induced motor activity in mice.
The effect of adenosine receptor ligands on dizocilpine-induced locomotion was studied in mice. Dizocilpine-induced hyperactivity (0.1 mg/kg ip) in mice was antagonized by all adenosine receptor agonists: CPA - A(1) rece...
Microarray analysis of altered gene expression in diallyl trisulfide-treated HepG2 cells.
Diallyl trisulfide (DT) is a natural compound derived from garlic. Despite its reported lipid-lowering effects, the mechanisms of its actions are not clear yet. To further understand the molecular mechanisms of actions o...