Characterization of bioactive compounds from Ficus vallis-choudae Delile (Moraceae)
Journal Title: Trends in Phytochemical Research - Year 2017, Vol 1, Issue 4
Abstract
Ficus vallis-choudae Delile has been reported to exhibit antifungal, anticonvulsant, anti-inflammatory and antinociceptive activities. Herein we report the first ever pharmacochemical studies on the figs of Ficus vallis-choudae resulting in isolation of a new ceramide named nkwenamide (1). Also, seven known compounds including the binary mixture of β-amyrin palmitate (2) and lupeol palmitate (3), olean-12-en-3-one (4), n-hexacosan-1-ol (5), β-sitosterol (6), and mixture of β-amyrin (7) and lupeol (8) were isolated. Their structures were elucidated using spectroscopic methods. The methanol extract of the figs of this plant exhibited urease, and α-glucosidase activities and showed DPPH radical scavenging potency with IC50 values, 61.7, 73.7 and 87.4 µg/mL, respectively. It also showed a weak chemiluminescence activity as compared to ibuprofen. The mixture of 2 and 3 exhibited maximum urease inhibitory activity with IC50 value 23.9 µg/mL while the mixture of 7 and 8 showed the maximum α-glucosidase inhibition with IC50 value 44.0 µg/mL. All the isolates showed weak chemiluminescence activity.
Authors and Affiliations
Jean Jules Kezetas Bankeu, Amadou Dawé, Marius Mbiantcha, Guy Raymond Feuya, Iftikhar Ali, Marthe Aimée Tchuente Tchuenmogne, Lateef Mehreen, Bruno Lenta, Muhammad Ali, Augustin Silvère Ngouela
Keywords
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